慢性肾脏病107例患者中医证素分布特点  

Distribution characteristics of traditional Chinese medicine syndrome elements in 107 patients with chronic kidney disease

作　　者：廖林丽 李翔[1] 邓颖 李新宇 彭清华[1,2] LIAO Lin-li;LI Xiang;DENG Ying;LI Xin-yu;PENG Qing-hua(Hunan University of Chinese Medicine,Changsha 410208,China;The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)

机构地区：[1]湖南中医药大学,长沙410208 [2]湖南中医药大学第一附属医院,长沙410007

出　　处：《中华中医药杂志》2022年第11期6682-6686,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：湖南中医药大学中医学国内一流建设学科项目(No.湘教通[2018]469号),湖南中医药大学研究生培养质量工程项目(No.2019CX41);湖南省中医药科研计划重点项目(No.201901);湖南省研究生科研创新项目(No.CX20200790,No.CX20200789)。

摘　　要：目的:分析慢性肾脏病(CKD)患者中医证素分布特点,为CKD的规范化辨证及临床用药提供参考。方法:通过横断面研究及现场问卷的方式,规范采集107例CKD患者的一般情况资料和中医四诊资料,依据《证素辨证学》,运用“WF文锋-Ⅲ中医(辅助)诊疗系统”客观提取CKD患者的证素。利用Excel 2019分析CKD患者证素分布特点,同时,运用SPSS Modeler 18.0统计软件中Apriori算法进行CKD患者高频证素之间的关联规则分析。结果:共提取证素30项,累计出现频次505次。高频证素(出现频率>12%)有14项,其中病位证素6项,分别为肾、脾、心神、肺、肝、胃;病性证素8项,分别为湿、气虚、水停、血虚、阴虚、痰、热、阳虚。K1组(CKD 1~2期)排名前10的高频证素有湿、肾、水停、气虚、脾、阴虚、心神、肺、热、血虚。K2组(CKD 3~5期)排名前10的高频证素有肾、气虚、血虚、湿、脾、水停、痰、阴虚、心神、热。关联规则分析中,规则置信度≥85%的证素组合有29对,提取了规则置信度排名前10的证素组合。结论:CKD病情复杂,中医证素分布广,涉及脏腑、气血、阴阳、津液等。CKD病位证素主要为肾、脾两脏,病性证素主要为湿、气虚、水停、血虚。Objective:To analyze the distribution characteristics of traditional Chinese medicine(TCM)syndrome elements in patients with chronic kidney disease(CKD),and provide reference for standardized syndrome differentiation and clinical medication of CKD.Methods:Through cross-sectional study and on-site questionnaire,the general information of 107patients with CKD and the data of TCM were collected uniformly and standardized,according to Syndrome Differentiation of Syndrome Elements,‘WF Wenfeng-ⅢTCM(auxiliary)diagnosis and treatment system’was used to standardize the extraction element.Excel 2019 was used to analyze the distribution characteristics of syndrome elements in patients with CKD,and the Apriori algorithm in SPSS Modeler 18.0 statistical software was used to analyze the association rules between high-frequency syndrome elements in patients with CKD.Results:A total of 30 syndrome elements were presented,with a total frequency of 505times.There were 14 high frequency syndrome elements(frequency>12%),of which 6 disease location syndrome elements were kidney,spleen,mind,lung,liver and stomach.There were 8 disease syndrome elements,including dampness,qi deficiency,water stagnation,blood deficiency,yin deficiency,phlegm,heat and yang deficiency.The top 10 high-frequency syndrome elements in K1 group(CKD 1~2 phase)were dampness,kidney,water stagnation,qi deficiency,spleen,yin deficiency,mind,lung,heat and blood deficiency.The top 10 high-frequency syndrome elements in the K2 group(CKD 3~5 phase)were kidney,qi deficiency,blood deficiency,dampness,spleen,water stagnation,phlegm,yin deficiency,mind and heat.In the association rule analysis,there were 29 pairs of syndrome elements with rule confidence≥85%,and the top 10 pairs syndrome elements with rule confidence were extracted.Conclusion:CKD is a complicated disease,and TCM syndrome elements are widely distributed,involving zang-fu organs,qi and blood,yin and yang,body fluid,etc.The main disease location syndrome elements of CKD patients are kidney and spleen,a

关 键 词：慢性肾脏病 证素 分布特点 病位证素 病性证素 

分 类 号：R277.5[医药卫生—中医学]