Catalytic Atroposelective Catellani Reaction Enables Construction of Axially Chiral Biaryl Monophosphine Oxides  

作　　者：Qiang Feng Xingxing Ma Wen Bao Shi-Jun Li Yu Lan Qiuling Song 

机构地区：[1]Institute of Next Generation Matter Transformation,College of Chemical Engineering,College of Material Sciences Engineering,Huaqiao University,Xiamen 361021 [2]Key Laboratory of Molecule Synthesis and Function Discovery,College of Chemistry,Fuzhou University,Fuzhou 350108 [3]School of Pharmacy,State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000 [4]Green Catalysis Center,College of Chemistry,Zhengzhou University,Zhengzhou 450001 [5]School of Chemistry and Chemical Engineering,Chongqing Key Laboratory of Theoretical and Computational Chemistry,Chongqing University,Chongqing 400030

出　　处：《CCS Chemistry》2021年第12期377-387,共11页中国化学会会刊（英文）

基　　金：Financial support from National Natural Science Foundation of China(nos.21772046 and 2193103)is gratefully acknowledged.

摘　　要：An unprecedented atroposelective Catellani reaction between phosphine oxide-containing aryl bromides,aryliodides,and nucleophiles for the construction of phosphine-containing biaryl atropisomers was established using an enantiopure norbornene derivative as the chiral mediator.A broad range of atropisomeric biaryl-based monophosphine oxides were obtained in good efficiency with excellent enantioselectivity.

关 键 词：axial chirality BIARYLS Catellani reaction atroposelectivity biaryl monophosphine oxides 

分 类 号：O62[理学—有机化学]