Merging C–H and C–C Activation in Pd(Ⅱ)-Catalyzed Enantioselective Synthesis of Axially Chiral Biaryls  

作　　者：Hao-Ming Chen Gang Liao Cheng-Kai Xu Qi-Jun Yao Shuo Zhang Bing-Feng Shi 

机构地区：[1]Department of Chemistry,Zhejiang University,Hangzhou 310027 [2]School of Biotechnology and Health Sciences,Wuyi University,Jiangmen 529020

出　　处：《CCS Chemistry》2021年第12期455-465,共11页中国化学会会刊（英文）

基　　金：The authors gratefully acknowledge financial support from the NSFC(nos.21772170 and 21925109 for B.-F.S.and no.21901228 for G.L.);Outstanding Young Talents of Zhejiang Province High-level Personnel of Special Support(no.ZJWR0108 for B.-F.S.).

摘　　要：The merging of C-H and C-C bond cleavage into one single chemical process remains a daunting challenge,especially in an asymmetric manner.Herein,a Pd(Ⅱ)-catalyzed enantioselective tandem C-H/C-C activation for the synthesis of axially chiral biaryls is described.Two types of simple cyclopropanes,such as vinylcyclopropanes and cyclopropanols,were used as efficient and readily available coupling partners.

关 键 词：palladium C–H activation C–C cleavage atroposelectivity axially chiral biaryls 

分 类 号：O64[理学—物理化学]