针药联合治疗肝郁型原发性开角型青光眼的临床研究  

Clinical Study on Acupuncture-Medication Combination in Treating Primary Open Angle Glaucoma of Liver Depression

作　　者：于潇[1] 孙河[2] YU Xiao;SUN He(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中医药信息》2023年第1期52-56,共5页Information on Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82074497)。

摘　　要：目的:观察自拟疏肝明目汤联合针刺治疗肝郁型原发性开角型青光眼(primary open angle glaucoma, POAG)的临床疗效。方法:将符合纳入标准的60例(102只眼)肝郁型POAG患者依据随机数字表随机分为观察组30例(52只眼)和对照组30例(50只眼)。对照组给予西医基础治疗,观察组在对照组基础上联合疏肝明目汤和针刺治疗,两组均治疗30 d。比较两组患者治疗前后眼压、视力、视野平均缺损(mean of defect,MD)以及视野平均光敏度(mean of sensitive,MS)变化情况,并比较临床疗效。结果:治疗后观察组总有效率(73.08%,38/52)高于对照组(52%,26/50)(P <0.05)。治疗前,两组患者眼压、视力、MD和MS比较,差异无统计学意义(P> 0.05)。治疗后,对照组患者眼压较治疗前降低(P <0.05);观察组眼压、MD较治疗前降低(P <0.05),MS较治疗前升高(P <0.05);且治疗后观察组眼压、MD、MS改善情况优于对照组(P <0.05)。治疗后两组视力均未发现明显改善异,无统计学意义(P>0.05)。结论:疏肝明目汤联合针刺治疗肝郁型POAG可以有效提高临床总有效率,改善视野光敏度,降低眼压和视野缺损,但对视力无明显改善作用。Objective: To observe the clinical efficacy of self-made prescription Shugan Mingmu Decoction combined with acupuncture in treatment of primary open angle glaucoma(POAG) of Liver depression type.Methods: A total of 60 patients(102 eyes) with POAG of Liver depression type, who met the inclusion criteria, were randomly divided into the observation group(n = 30, 52 eyes) and the control group(n = 30, 50 eyes). The control group was given basic western medication;on which basis, the observation group was also treated with Shugan Mingmu Decoction and acupuncture. Both groups were treated for 30 d. The changes in intraocular pressure, visual acuity, mean deviation(MD) and mean sensitive(MS) of visual fields were compared between the two groups. The clinical efficacy was also compared between the two groups. Results: The total effective rate was 73. 08%(38/52) in the observation group, which was significantly higher than 52%(26/50) in the control group(P<0.05). There were no statistical differences in intraocular pressure, visual acuity, MD and MS between the two groups before the treatment(P > 0. 05);the intraocular pressure was decreased after the treatment compared with that before the treatment in the control group(P<0.05). The intraocular pressure and MD were decreased after the treatment compared with those before the treatment(P <0. 05), and MS was increased after the treatment compared with that before the treatment in the observation group(P<0.05). The improvements of intraocular pressure, MD and MS were more significant in the observation group than those in the control group after the treatment(P<0.05). There was no significant difference in visual acuity between before and after the treatment in the two groups(P > 0. 05).Conclusion: Shugan Mingmu Decoction combined with acupuncture can effectively improve the total clinical effective rate, improve MS, reduce intraocular pressure and MD, but it has no obvious effect on visual acuity improvement in treatment of POAG.

关 键 词：疏肝明目汤 针刺 青光眼 

分 类 号：R276.7[医药卫生—中医五官科学]