黄芪有效成分抗动脉粥样硬化机制研究进展  

Mechanism Research Progress in Active Ingredients of Astragalus in Treating Arteriosclerosis

作　　者：王丽娜 张磊[2] 戴霞[1] WANG Lina;ZHANG Lei;DAI Xia(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]山东中医药大学附属医院,山东济南250011

出　　处：《中医药信息》2023年第1期68-74,共7页Information on Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81974561)。

摘　　要：动脉粥样硬化(atherosclerosis,AS)是冠心病、脑卒中等心脑血管疾病的病理基础,目前临床以他汀类等降脂药物治疗为主,但安全性备受争议。因此,探索一种安全有效的替代疗法是现阶段研究AS的主要任务。现代药理学研究证实黄芪及其有效成分具有抗AS的功效,并且具有多通路、多靶点的特点。然而,现阶段研究大多集中在黄芪单个有效成分抗AS的机制。因此,笔者通过整理相关文献总结黄芪有效成分抗AS的作用机制,以参与AS病理过程的主要细胞为主线,发现黄芪有效成分可以从保护内皮细胞、阻止巨噬细胞自噬、抑制血管平滑肌细胞增殖和迁移以及抗血小板聚集4个方面发挥抗AS的作用。Arteriosclerosis(AS) is the pathological basis of coronary heart disease, at present it is mainly treated with statins and the safety of the medication is controversial. Therefore, to explore a safe and effective alternative therapy is the main research task of AS at this stage. Astragalus and its active components have anti-AS effect with multi-pathway and multi-target characteristics. However, most studies focus on the mechanism of single effective component of astragalus in treating AS. This study summarized the mechanism of anti-AS effect of astragalus by reviewing the related literature. Taking the main cells involved in the pathological process of AS as the main line, it is found that astragalus can play the role in anti-AS from the perspective of protecting endothelial cells, preventing autophagy of macrophages, inhibiting proliferation and migration of vascular smooth muscle cells and preventing platelet aggregation.

关 键 词：黄芪 动脉粥样硬化 黄芪多糖 黄芪甲苷 黄芪黄酮 

分 类 号：R285[医药卫生—中药学]