人体重要寄生虫重组TPx参与免疫调控、免疫诊断及免疫预防的研究进展  

Research progress of recombinant thioredoxin peroxidase of important human parasites involved in immunoregulation,immunodiagnosis and immunoprophylaxis

作　　者：何威 罗波 周必英 He Wei;Luo Bo;Zhou Biying(Department of Parasitology,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学寄生虫学教研室,遵义563000

出　　处：《中华地方病学杂志》2022年第10期856-860,共5页Chinese Journal of Endemiology

基　　金：国家自然科学基金(81960378);遵义市校联合基金(遵市科合HZ字[2021]278号);遵义医科大学学术新苗培养及创新探索专项(黔科合平台人才[2020]-004);遵义医科大学研究生教育创新计划(ZYK70)。

摘　　要：硫氧还蛋白过氧化物酶(TPx)属于过氧化物氧还蛋白超家族一员,广泛表达于寄生虫各个生长发育阶段及其排泄分泌物中。一方面,重组TPx蛋白可参与宿主免疫调控;另一方面,重组TPx蛋白作为诊断性抗原具有较高的敏感性和特异性,可用于寄生虫病的免疫诊断;此外,还可作为候选疫苗分子用于寄生虫病的免疫预防。文中就人体重要寄生虫重组TPx蛋白对宿主免疫调控、免疫诊断及免疫预防的研究进展做一综述。Thioredoxin peroxidase(TPx)belongs to the superfamily of peroxiredoxins,which is widely expressed in various growth and development stages of parasites and their excretory secretions.On the one hand,recombinant TPx protein can participate in host immunoregulation;on the other hand,recombinant TPx protein has high sensitivity and specificity as a diagnostic antigen,and can be used for immunodiagnosis of parasitic diseases;in addition,it can also be used as a candidate vaccine molecule for the immunoprophylaxis of parasitic diseases.This paper reviews the research progress on host immunoregulation,immunodiagnosis and immunoprophylaxis by recombinant TPx protein of important human parasites.

关 键 词：寄生虫 硫氧还蛋白过氧化物酶 免疫调控 免疫诊断 免疫预防 

分 类 号：R392[医药卫生—免疫学]