红细胞在感染免疫应答中的作用研究进展  

The role of red blood cells in immune response to infection:A review

作　　者：张经昂 张赟 唐康 马樱 张春梅 庄然 金伯泉 张宇丝 ZHANG Jingang;ZHANG Yun;TANG Kang;MA Ying;ZHANG Chunmei;ZHUANG Ran;JIN Boquan;ZHANG Yusi(Department of Immunology,Air Force Medical University,Xi'an 710032,China)

机构地区：[1]空军军医大学基础医学院免疫学教研室,陕西西安710032

出　　处：《细胞与分子免疫学杂志》2022年第11期1044-1050,共7页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金青年项目(81701555);陕西省自然科学基础研究计划(2018JQ8060)。

摘　　要：红细胞是血液中数量最多的一种细胞,除了运送氧气和二氧化碳,在免疫应答中还发挥了调节作用。研究认为,红细胞是机体抗感染免疫的一道防线,可通过免疫黏附作用发挥清除免疫复合物、促进吞噬、促进抗原提呈等功能,或通过参与氧化应激反应、与其他淋巴细胞直接发生相互作用,从而调节感染免疫应答。另外,当病原体入侵时,机体抗感染免疫应答诱发的炎症反应,可引起一系列免疫病理损伤,导致红细胞的成熟过程、形态和功能发生变化。我们总结了红细胞在感染免疫应答中的作用相关最新研究进展,以期为揭示相关疾病的发病机制以及探索药物作用靶点提供参考依据。Red blood cells are the largest number of cells in blood.Apart from transporting oxygen and carbon dioxide,they also regulate the immune responses.It has been confirmed that red blood cells can play a role in clearing immune complex,promoting phagocytosis,and presenting antigen through immune adhesion.They can also regulate the immune response by participating in the oxidative stress or interacting with the other lymphocytes.Furthermore,when pathogens invading,the host will exert anti-infective immune response and also induce inflammatory response,causing a series of immunopathological injuries,which may bring changes to the red blood cells'maturation process,their morphology,and functionality.This review summarizes recent progresses on the roles and mechanisms of red blood cells in anti-infectious immunity,providing theoretical basis for revealing pathogenesis and exploring therapeutic targets.

关 键 词：成熟红细胞 有核红细胞 感染免疫 免疫黏附 综述 

分 类 号：R392.12[医药卫生—免疫学] C353.11[医药卫生—基础医学]