5种方法治疗中度痤疮的疗效比较研究  

Comparison of five therapeutic methods in treatment of moderate acne vulgaris

作　　者：涂颖[1] 江弘婧 杨成 黄小凤 杨建婷 何黎[1] Tu Ying;Jiang Hongjing;Yang Cheng;Huang Xiaofeng;Yang Jianting;He Li(Department of Dermatology,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China;Department of Dermatology,Kunming Children's Hospital,Kunming 650034,China;Winona Cosmetic-Dermatology Center,Kunming 650106,China)

机构地区：[1]昆明医科大学第一附属医院皮肤科,昆明650032 [2]昆明市儿童医院皮肤科,昆明650034 [3]薇诺娜皮肤医疗美容中心,昆明650106

出　　处：《中华医学美学美容杂志》2022年第6期500-504,共5页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：教育部创新团队发展计划(IRT17-R49);云南省科技领军人才项目(2017HA010);云南省重大科技专项(2018ZF005)。

摘　　要：目的探讨药物分别联合红蓝光、果酸、强脉冲光治疗中度痤疮的疗效。方法2014年10月至2015年10月,昆明医科大学附属第一医院皮肤科及薇诺娜皮肤医疗美容中心诊治的中度痤疮患者187例,男59例、女128例;年龄16~29(21.79±2.52)岁。分为治疗A组(仅口服药物)51例、治疗B组(口服药物联合红蓝光)38例、治疗C组(口服药物联合果酸)42例、治疗D组(口服药物联合强脉冲光)26例、治疗E组(口服药物联合果酸及强脉冲光)30例5组;观察各组治疗前后皮损(粉刺、丘疹、脓疱、结节、囊肿)数量变化,比较5种治疗方法对粉刺、丘疹、脓疱和总皮损消退率、有效率,评估各治疗方法的优劣性。结果治疗E组中,患者粉刺(86.37±9.64)%、丘疹(94.25±9.79)%、总皮损(88.80±9.40)%消退率及有效率(96.7%)明显优于其他4组(P<0.05);治疗C组中患者粉刺消退率(70.91±18.52)明显优于治疗A、B组(P<0.05);治疗D组中患者炎性丘疹皮损消退率(91.42±13.86)明显优于治疗A、B组(P<0.05)。结论中度痤疮可优先选择口服药物联合果酸及强脉冲光的治疗方法,口服药物联合果酸对中度痤疮的粉刺有明显改善作用,而口服药物联合强脉冲光对中度痤疮的炎性丘疹也有明显改善作用,值得临床应用。Objective To observe the efficacy of drug combined with red-blue light irradiation,chemical peeling by glycolic acid and intense pulsed light(IPL)in the treatment of moderate acne vulgaris.Methods A total of 187 patients with moderate acne vulgaris were divided into five groups.There were 59 males and 128 females,aged from 16 to 29 years(21.79±2.52).In group A,patients were treated with oral medicines;the patients were treated with oral medicines combined with red-blue light irradiation,chemical peeling by glycolic acid and IPL respectively in group B,group C and group D.In group E,patients were treated with oral medicines combined with chemical peeling by glycolic acid and IPL.The number of different types of skin lesions(comedoes,papules,pustules)were compared between before and after treatment in five groups.The clinical effect of five treatment groups was evaluated by comparing regression rates of different types of skin lesions and total skin lesions and treatment efficiency.Results All the patients with moderate acne vulgaris were brought into this study.The regression rates of comedoes,papules and total skin lesions were(86.37±9.64)%,(94.25±9.79)%and(88.80±9.40)%respectively in group E,and significantly higher than that of other four groups(P<0.05).The treatment efficiency of group E also were significantly higher than that of other four groups(P<0.05).Then,the regression rates of comedoes(70.91±18.52)in group C was significantly higher than that of group A and group B(P<0.05).The regression rates of papules(91.42±13.86)in group D was significantly higher than that of group A and group B(P<0.05).Conclusions Oral medicines combined with chemical peeling by glycolic acid and IPL has obvious clinical efficacy in treatment of patients with moderate acne vulgaris.Oral medicines combined with chemical peeling by glycolic acid can obviously improve comedoes,and oral medicines combined with IPL can obviously improve papules.

关 键 词：寻常痤疮 中度 红蓝光 果酸 强脉冲光 米诺环素 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]