中西医结合治疗阻塞性睡眠呼吸暂停低通气综合征30例临床观察  

Clinical Observstion on 30 Cases of Obstructive Sleep Apnea Hypopnea Syndrome with Integrated Traditional Chinese and Western Medicine

作　　者：朱晓珏 蒋紫云[1] 连乐燊[1] 李碧芳 谢小君 王应康 陶海澜 ZHU Xiaojue;JIANG Ziyun;LIAN Leshen;LI Bifang;XIE Xiaojun;WANG Yingkang;TAO Hailan(Dongguan Hospital of Guangzhou University of Traditional Chinese Medicine(Dongguan Hospital of Traditional Chinese Medicine),Dongguan 523000,China)

机构地区：[1]广州中医药大学东莞医院(东莞市中医院),广东东莞523000

出　　处：《中国民族民间医药》2022年第24期100-104,共5页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：广东省中医药局科研项目(立项编号:20202223)。

摘　　要：目的:探索中西医结合治疗痰瘀互结证阻塞性睡眠呼吸暂停低通气综合征(OSAHS)30例临床观察。方法:选取60例中重度痰瘀互结证阻塞性睡眠呼吸暂停低通气综合征的患者为研究对象,随机分为两组,每组均为30例,分别为对照组和观察组。对照组给予常规治疗;观察组在对照组方案上每天内服加味半夏厚朴汤1剂,疗程为12周。观察两组中医证候疗效、睡眠呼吸暂停低通气指数(AHI)、Epworeh嗜睡量表(ESS)评分、最低血氧饱和度(LSaO2)、白细胞介素6(IL-6)、肿瘤坏死因子(TNF-ɑ)、丙二醛(MDA)、超氧化物歧化酶(SOD)的变化情况。结果:治疗后两组的AHI、ESS评分较治疗前均有显著性下降(P<0.05),且治疗后观察组AHI、ESS评分显著性低于对照组(P<0.05);治疗后两组的LSaO2较治疗前显著性升高(P<0.05),且治疗后观察组LSaO2显著性高于对照组(P<0.05);治疗后两组的血清IL-6、TNF-ɑ、MDA水平较治疗前均有显著性下降(P<0.05),且治疗后观察组IL-6、TNF-ɑ、MDA水平显著性低于对照组(P<0.05);治疗后两组的血清SOD水平较治疗前显著性升高(P<0.05),且治疗后观察组SOD水平显著性高于对照组(P<0.05);观察组的总有效率显著优于对照组(P<0.05);以上差异均有统计学意义。结论:加味半夏厚朴汤治疗痰瘀互结证OSAHS有效,推测其治疗机制是减轻炎症反应及氧化应激反应。Objective To explore the clinical observation of 30 cases of obstructive sleep apnea hypopnea syndrome(OSAHS) with phlegm and blood stasis syndrome treated by Traditional Chinese and Western Medicine.Methods 60 patients with moderate to severe obstructive sleep apnea hypopnea syndrome with phlegm and blood stasis syndrome were selected as the research object and randomly divided into two groups, each group was 30 cases, respectively as the control group and the observation group. The control group was given routine treatment, and the observation group was given 1 dose of Modified Banxia Houpo Decoction every day on the basis of treatment for the control group, the course of treatment lasted 12 weeks. The curative effect of TCM syndrome, sleep apnea hypopnea index(AHI), Epworeh Sleepiness Scale(ESS) score, lowest blood oxygen saturation(LSaO2), interleukin 6(IL-6), tumor necrosis factor(TNF-ɑ), malondialdehyde(MDA), superoxide dismutase(SOD) were observed in 2 groups.Results After treatment, AHI and ESS scores in the 2 groups were significantly decreased compared with those before treatment(P<0.05), and AHI and ESS scores in the observation group were significantly lower than those in the control group(P<0.05). After treatment, LSaO2in the two groups was significantly increased compared with that before treatment(P<0.05), and LSaO2in the observation group was significantly higher than that in the control group(P<0.05). After treatment, the levels of IL-6, TNF-ɑ and MDA in 2 groups were significantly decreased compared with those before treatment(P<0.05), and the levels of IL-6, TNF-ɑ and MDA in observation group were significantly lower than those in control group(P<0.05). After treatment, the SOD levelin the two groups was significantly higher than that before treatment(P<0.05), and the SOD level in the observation group was significantly higher than that in the control group(P<0.05). The total effective rate of the observation group was significantly better than that of the control group(P<0.05). The differen

关 键 词：加味半夏厚朴汤 阻塞性睡眠呼吸暂停低通气综合征 痰瘀互结证 

分 类 号：R56[医药卫生—呼吸系统]