炎症标记物及宫颈分泌物培养在无创诊断未足月胎膜早破并发绒毛膜羊膜炎中的价值  

The value of inflammatory markers and cervical secretion culture in the noninvasive diagnosis of premature rupture of membranes with chorioamnionitis

作　　者：黄柳英 杜宝丽 莫世盼 Huang Liuying;Du Baoli;Mo Shipan(Department of Obstetrics and Gynecology,Pingshan New District People rs Hospital,Shenzhen 518118,China)

机构地区：[1]深圳市坪山新区人民医院妇产科,广东深圳518118

出　　处：《实用妇科内分泌电子杂志》2022年第18期12-14,共3页Electronic Journal of Practical Gynecological Endocrinology

基　　金：深圳市坪山区卫生健康系统科研项目(编号202154)。

摘　　要：目的分析炎症标记物及宫颈分泌物培养在无创诊断未足月胎膜早破并发绒毛膜羊膜炎中的价值。方法选取100例未足月胎膜早破孕妇,按照术后胎盘病理结果分为绒毛膜羊膜炎组(44例)与非绒毛膜羊膜炎组(56例);并选择正常未足月孕妇50例为对照组。检测和对比三组血清炎症标记物[白介素-6(IL-6)、降钙素原(PCT)及C反应蛋白(CRP)]水平、宫颈分泌物培养结果。结果绒毛膜羊膜炎组IL-6、PCT及CRP水平高于非绒毛膜羊膜炎组、对照组,差异有统计学意义(P<0.05)。相比炎症标记物及宫颈分泌物培养单独诊断,炎症标记物、宫颈分泌物培养联合诊断敏感性、特异性、阳性预测值、阴性预测值及准确率较高,差异具有统计学意义(P<0.05)。结论采用炎症标记物联合宫颈分泌物培养可预测未足月胎膜早破孕妇绒毛膜羊膜炎的发生。Objective To analyze the value of inflammatory markers and cervical secretion culture in the noninvasive diagnosis of premature rupture of membranes with chorioamnionitis.Methods 100 pregnant women with premature rupture of membranes before term were selected and divided into chorionic amnitis group(44 cases)and non-chorionic amnitis group(56 cases)according to the results of postoperative placental pathology.50 normal pregnant women were selected as control group.The levels of serum inflammatory markers[interleukin-6(IL-6),procalcitonin(PCT)and C-reactive protein(CRP)]and the culture results of cervical secretions in the three groups were detected and compared.Results The levels of IL-6,PCT and CRP in chorionic amniotic group were higher than those in non-chorionic amniotic group and control group,and the difference was statistically significant(P<0.05).Compared with the diagnosis of inflammatory markers and cervical secretion culture alone,the combined diagnosis of inflammatory markers and cervical secretion culture had higher sensitivity,specificity,positive predictive value,negative predictive value and accuracy,and the difference was statistically significant(P<0.05).Conclusion The use of inflammatory markers combined with cervical secretion culture can predict the occurrence of chorioamnionitis in preterm premature rupture of membranes.

关 键 词：未足月胎膜早破 绒毛膜羊膜炎 炎症标记物 

分 类 号：R714.433[医药卫生—妇产科学]