全自动凯氏定氮仪法测定清开灵口服液的总氮量  

To Determine the Total Nitrogen Content of Qingkailing Oral Liquid by Full-automatic Kjeldahl Method

作　　者：董丽荣 DONG Lirong(Kunming Institute for Food and Drag control,Kunming 653100,China)

机构地区：[1]昆明市食品药品检验所,云南昆明650100

出　　处：《中国民族民间医药》2022年第22期39-41,共3页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:采用全自动凯氏定氮仪对清开灵口服液的总氮量进行测定,优选测定参数。方法:采用均匀设计法优化凯氏定氮仪测定总氮的实验条件,并验证该方法的精密度与准确性。结果:消解最佳条件为硫酸加入量为10 mL,硫酸钾∶硫酸铜(9∶1)加入量为5 g,40%NaoH加入量为70 mL。回收率为100.3%,方法精密度RSD为2.2%。结论:全自动凯氏定氮仪测定总氮量准确、快捷、高效,可作为清开灵口服液总氮量测定的有效方法。Objective To determine the total nitrogen content of Qingkailing oral liquid by full-automatic kjeldahl method and optimize the determination parameters.Methods The experimental conditions were optimized by uniform design method,and the precision and accuracy of the method were verified.Results The optimum digestion conditions were as follows:HSO_(4)was 10 mL,K2 SO_(4)∶CuSO(9∶1)was 5.0 g,40%NaoH was 70 mL,the recovery was 100.3%,and the RSD of the method Precision was 2.2%.Conclusion The method is accurate,fast and efficient.It can be used as an effective method to determine the total nitrogen in Qingkailing oral liquid.

关 键 词：总氮量 全自动凯氏定氮仪法 清开灵口服液 

分 类 号：R284.1[医药卫生—中药学]