益肾固胎颗粒联合黄体酮胶丸早期防治脾肾两虚型滑胎30例临床观察  

Clinical Observation of Shengutai Granule Combined with Progesterone Capsule in the Early Prevention and Treatment of 30 Cases of Slippery Fetus with Deficiency of Spleen and Kidney

作　　者：李加云 余兆吉 丁朝阳 姜丽娟 LI Jiayun;YU Zhaoji;DING Chaoyang;JIANG Lijuan(Puer Hospital of traditional Chinese Medicine,Puer 665000,China;First clinical medical college,Yunnan University of Chinese Medicine,Kunming 650000,China;The First Affiliated Hospital of Yunnan University of Chinese Medicine,Kunming 650021,China)

机构地区：[1]普洱市中医医院,云南普洱665000 [2]云南中医药大学第一临床医学院,云南昆明650000 [3]云南中医药大学第一附属医院,云南昆明650021

出　　处：《中国民族民间医药》2022年第22期108-112,共5页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：国家自然科学基金地区科学基金项目(82060882);云南省重大科技专项计划--重大科技专项(生物医药),项目编号:2017ZF011。

摘　　要：目的:观察益肾固胎颗粒早期防治脾肾两虚型滑胎的临床疗效。方法:完全符合纳入标准的滑胎患者60例,随机分成两组,治疗组30例,予益肾固胎颗粒联合黄体酮胶丸口服;对照组30例,予黄体酮胶丸口服。所有患者自确诊子宫腔内妊娠后开始服药,均治疗至妊娠12周末。对比观察治疗前后患者主要临床症状、体征,治疗后2周末、治疗后4周末、治疗至孕12周末血清孕酮、β-HCG、雌二醇水平的变化,常规性彩超监测子宫腔内妊娠囊、胎儿生长发育状况;服用药物前、治疗至孕12周末时分别化验肝肾功的变化,全面评价益肾固胎颗粒的临床疗效及安全性。结果:两组相比而言,综合疗效比较差异性具有统计学意义(P<0.05)。两组临床症状总积分、中医证候积分、各项血清生殖激素、B超监测胎儿发育比较,差异均有统计学意义(P<0.05)。结论:益肾固胎颗粒可明显改善脾肾两虚型滑胎患者的临床症状,提高妊娠成活率,提高脾肾两虚型滑胎患者的血清雌二醇、孕酮、β-HCG水平,未出现明显不良反应及毒副作用,有很大的临床价值,应该进一步研究,让更多滑胎患者获益。Objective To observe the Benefit Kidney Solid Particles prescription mechanisms in the therapeutic effects of Early Habitual Abortion with type of Spleen-Kidney deficiency. Methods The 60 Habitual Abortion Patients were divided into two groups randomly, the treatment group and the control group, 30 cases in treatment group by the progesterone capsule and Benefit Kidney Solid Particles prescription and 30 cases in control group with pure progesterone capsule. All of the cases started to take the medicines when they were confirmed in gestation until 12 th weeks of their pregnancy.The paper observed mainly symptoms and signs of pregnancy at 4,8,12 weeks of progesterone, β-hCG, estradiol level changes, pregnancy 2,4,12 weeks of conventional type-B ultrasonic in the detection of intrauterine pregnancy gestation sac and fetal development, dynamic monitoring is necessary. Before treatment and at the end of treatment of until 12 th weeks of their pregnancy, liver and kidney function index changes were objective detected to evaluate the differences between the two groups. Results Compared with the two groups, the difference of comprehensive curative effect was statistically significant(P<0.05). There were significant differences in the total score of clinical symptoms, TCM syndrome score, serum reproductive hormones and fetal development monitored by B-ultrasound between the two groups(P<0.05).Conclusion Benefit Kidney Solid Particles prescription can improve the clinical symptoms of Early Habitual Abortion with type of Spleen-Kidney deficiency abortion, improve the success rate of pregnancy.improved different degree of Early Habitual Abortion with type of Spleen-Kidney deficiency patients serum estradiol(E2), progesterone(P), beta hCG(β-hCG) level, witiout obvious adverse reactions and side effects, which is a certain clinical value worthy of further study and more patients with sliding benefit.

关 键 词：滑胎 益肾固胎颗粒 脾肾两虚 

分 类 号：R271.41[医药卫生—中医妇科学]