亚健康的中医证候特点及用药规律文献研究  

Literature Research on Sub-healthy TCM Syndromes and Medication Rules

作　　者：冉茜[1] 李勇华[1] 姜兴鹏 RAN Qian;LI Yonghua;JIANG Xinpeng(The TCM department of Chongqing three gorges medical college,Wanzhou 404120,China;The hospital of Chongqing three gorges medical college,Wanzhou 404000,China)

机构地区：[1]重庆三峡医药高等专科学校中医学院,重庆万州404120 [2]重庆三峡医药高等专科学校附属医院,重庆万州404000

出　　处：《中国民族民间医药》2022年第22期113-118,共6页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：重庆市教委科学技术研究项目(KJQN201902713);重庆市卫健委名老中医药专家传承工作室建设项目(渝中医[2020]20号);重庆市中医药重点学科(中医基础理论)建设项目(渝中医[2021]16号)。

摘　　要：目的:总结亚健康的中医证候特点及用药规律。方法:检索中国知网、维普数据库、万方期刊数据库、中国生物医学文献数据库建库以来至2021年1月1日,中医或中西医结合治疗亚健康的临床研究。提取纳入研究文献中的证候、证候要素、药物信息建立数据库,分别统计证候类型、证候要素、药物类别及药物分布情况,对高频药物进行二项、三项关联分析及聚类分析。结果:共纳入文献79篇。证候类型44个,前3位为肝郁脾虚(18)、心脾两虚(14)、肝郁气滞(11)。病位证素7个,前4位为脾(54)、肝(48)、肾(34)、心(31)。病性证素12个,前3位为气虚(56)、气郁(37)、血虚(26)。使用中药133味,前3位为茯苓(60)、甘草(57)、白术(53);涉及19个类别,前3位为补虚药(41)、清热药(13)、安神药(10);药物归经前3位为肝经(67)、肾经(50)、脾经(48);用药频次≥10次的35味药物中,置信度≥80%的二项关联30对,三项关联126组,聚类分析结果显示,存在5个核心药物群。结论:亚健康以肝郁脾虚最为常见,主要病变涉及肝、脾、肾、心四脏,应注重脏腑间的密切联系,整体施治;用药以补虚药为主,涉及三个基本方即六味地黄丸、归脾汤及柴胡疏肝散,组方思路以补益气血、滋阴补肾、疏肝健脾、温通经脉为要。Objective Summarize the distribution of sub-healthy TCM syndromes and medication rules.Methods This paper takes Databases of CNKI, Wanfang Data, VIP and CBM as the retrieval source, using the computer to retrieve the related clinical literature of TCM or Integrated TCM and Western Medicine treatment on Sub-health, which was published from the time of the establishment of the database to January 1, 2021. Symptoms, syndrome elements, and drug information included in the research literature were extracted to establish a database, and statistics were collected on syndrome types, syndrome elements, drug categories, and drug distribution. Binomial, trinomial correlation analysis and cluster analysis were performed for high frequency drugs.Results A total of 79 articles were included. There are 44 types of syndromes, the top 3 of which are liver stagnation and spleen deficiency(18), heart and spleen deficiency(14), and liver stagnation and qi stagnation(11).There are 7 disease location, and the top 4 frequency distributions are spleen(54), liver(48), kidney(34), and heart(31). There were 12 pathogenicity types, and the top 3 frequencies were Qi deficiency(56), Qi depression(37), and blood deficiency(26). 133 Chinese medicines are used, involving 19 categories. The top 3 are tonic drugs(41), clearing away heat(13), tranquilizers(10). The first 3 drugs meridian tropism are liver meridian(67), kidney meridian(50), and spleen meridian(48). Among the 35 drugs with a frequency of medication ≥10 times, there are 30 pairs of binomial associations, and 126 groups for the three associations. The cluster analysis results show that there are 5 core drug groups. Conclusion For sub-health, liver stagnation and spleen deficiency are the most common. The main pathological changes of the viscera are liver, spleen, kidney and heart. In the treatment of sub-health, attention should be paid to the close connection between zang-fu organs and holistic treatment.The main medication is tonifying deficiency medicine. Three basic prescriptions

关 键 词：亚健康 中医证候 用药规律 数据挖掘 

分 类 号：R241[医药卫生—中医诊断学]