腹型肥胖症患者血清网膜素1表达水平与代谢指标的相关性研究  

Study on the relationship between serum Omentin-1 and metabolic parameters in patients with abdominal obesity

作　　者：吴宇婷 孙晓芳[1,2] 刘彦 佘敦敏[1,2] 李影 Wu Yuting;Sun Xiaofang;Liu Yan;She Dunmin;Li Ying(Department of Endocrinology,Subei People's Hospital of Jiangsu Province,Yangzhou 225001,China;Now Department of Nursing,Zhongshan Hospital,Shanghai 200030,China)

机构地区：[1]江苏省苏北人民医院内分泌代谢科,扬州225001 [2]复旦大学附属中山医院护理部,上海200030

出　　处：《中国综合临床》2022年第6期488-493,共6页Clinical Medicine of China

基　　金：江苏省苏北人民医院博士启动基金(BSQDJ0059)。

摘　　要：目的分析腹型肥胖症患者血清网膜素1与体脂成分、胰岛素抵抗等代谢指标的相关性及临床意义。方法回顾性分析2018年1月至2021年12月在江苏省苏北人民医院肥胖多学科诊疗中心诊治的成人腹型肥胖症患者150例,同时随机选取同期健康体检者150名作为正常对照组。检测空腹血清网膜素1和糖脂代谢指标,计算稳态模型评估的胰岛素抵抗指数。应用生物电阻抗测定全身体脂分布。采用Pearson相关检验及多因素线性回归模型进行数据分析。结果腹型肥胖症患者血清网膜素1水平为(36.97±6.99)µg/L,正常对照组为(72.35±6.09)µg/L,组间比较差异有统计学意义(t=46.69,P<0.001)。腹型肥胖症患者体脂肪含量为(43.40±14.59)kg,正常对照组为(13.78±4.13)kg,组间比较差异有统计学意义(t=23.93,P<0.001)。腹型肥胖症患者空腹胰岛素为29.05(22.01,34.60)pmol/L,正常对照组为127.90(84.08,201.45)pmol/L,组间比较差异有统计学意义(Z=14.75,P<0.001)。腹型肥胖症患者胰岛素抵抗指数为0.87(0.68,1.05),正常对照组为4.19(2.77,7.31),组间比较差异有统计学意义(Z=14.75,P<0.001)。Pearson相关性分析显示,血清网膜素1与BMI、腰围、腰臀比、体脂肪含量、内脏脂肪面积、胰岛素抵抗指数、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、组别均呈显著负相关(r值分别为-0.825、-0.843、-0.756、-0.777、-0.835、-0.583、-0.429、-0.353、-0.503、-0.938,均P<0.001),与高密度脂蛋白胆固醇呈显著正相关(r=0.528,P<0.001),与年龄、性别无相关性(r值分别为-0.093、-0.040,P值分别为0.669、0.489)。多因素逐步回归分析显示,腹型肥胖组患者的内脏脂肪面积与血清网膜素1呈独立负相关(非标化系数准=-0.026,t=2.250,非标准化系数95%CI-0.049~-0.003,P=0.026)。结论腹型肥胖症患者血清网膜素1表达水平较正常人显著降低,且与体脂分布、胰岛素抵抗状态密切相关。内脏脂肪面积是影�Objective To investigate the level of serum Omentin-1 in subjects with abdominal obesity,and to analyze the influencing factors of Omentin-1 and its relationship with body fat distribution,insulin resistance and metabolic parameters.Methods A retrospective case-control study was conducted to analyze the clinical data of one hundred and fifty adults with abdominal obesity(BMI≥28 kg/m2)who were randomly selected from Obesity Multidisciplinary Diagnosis and Treatment Center,Subei People's Hospital from Januray 2018 to December 2021.Meanwhile,150 healthy adults were enrolled as a normal control group.Fasting serum Omentin-1 and glucose metabolism were measured,and homeostasis model assessment of insulin resistance index(HOMA-IR)was calculated.Body fat composition was measured by bioelectrical impedance analysis.The relationship between Omentin-1 and other variables were presented by the Pearson correlation coefficients.Stepwise regression model was used to analyze the influencing factors of Omentin-1.Results The serum omentin-1 level of patients with abdominal obesity was(36.97±6.99)µg/L,that of normal control group was(72.35±6.09)µg/L.The difference between the two groups was statistically significant(t=46.69,P<0.001).The body fat level of patients with abdominal obesity was(43.40±14.59)kg,that of normal control group was(13.78±4.13)kg.The difference between the two groups was statistically significant(t=23.93,P<0.001).The fasting insulin of patients with abdominal obesity was 29.05(22.01,34.60)pmol/L,that of normal control group was 127.90(84.08,201.45)pmol/L.The difference between the two groups was statistically significant(Z=14.75,P<0.001).The HOMA-IR of patients with abdominal obesity was 0.87(0.68,1.05),that of normal control group was 4.19(2.77,7.31).The difference between the two groups was statistically significant(Z=14.75,P<0.001).Pearson linear correlation analysis showed that serum omentin-1 levels were negatively correlated with BMI,waist circumference,waist-hip ratio(WHR),body fat,visceral Fat

关 键 词：网膜素1 腹型肥胖 体脂分布 内脏脂肪 体质量指数 

分 类 号：R589.2[医药卫生—内分泌]