超声造影在预测脉冲波高强度聚焦超声治疗不可切除胰腺癌患者生存时间中的作用  

The role of contrast-enhanced ultrasound in predicting survival time of patients with unresectable pancreatic cancer treated by pulsed wave high intensity focused ultrasound

作　　者：杨宇[1] 史宪全[1] 钱林学[1] Yang Yu;Shi Xianquan;Qian Linxue(Department of Ultrasound,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院超声科,北京100050

出　　处：《中国医刊》2023年第2期183-186,共4页Chinese Journal of Medicine

基　　金：北京市医院管理局“登峰”计划专项经费资助(DFL201800102)。

摘　　要：目的 探讨超声造影定量参数在预测脉冲波高强度聚焦超声(pulsed wave high intensity focused ultrasound,pHIFU)治疗不可切除胰腺癌患者生存时间中的作用。方法 选取2020年2月至2021年3月就诊于首都医科大学附属北京友谊医院并经pHIFU治疗的不可切除胰腺癌患者。记录患者年龄、性别、临床分期、肿瘤体积、单位体积能量及生存时间。收集其治疗前后超声造影定量参数,包括上升强度(rise intensity,RI)、上升时间(rise time,RT)、上升支斜率(raise rate,Raise R),并计算相对强度(relative rise intensity,rRI)=100%×RI(肿瘤内)/RI(参考动脉)、相对上升支斜率(relative raise rate,rRaise R)=100%×RaiseR(肿瘤内)/RaiseR(参考动脉)。将上述参数的治疗前测量值与治疗后测量值进行比较,若治疗后测量值大于治疗前测量值,则该患者归类为该参数的上升组,反之为下降组。分析超声造影定量参数的变化对患者生存时间的预测价值。结果 共入组患者19例,所有患者自接受pHIFU至死亡的中位生存时间为184d。Kaplan-Meier生存分析结果显示pHIFU治疗后rRaise R上升组患者生存时间曲线优于rRaise R下降组(P=0.027),其中位生存时间分别为301d及114d,两组患者年龄、性别、临床分期、肿瘤体积、单位体积能量比较差异均无显著性(P>0.05)。结论 不可切除胰腺癌患者经pHIFU治疗后,肿物超声造影定量参数的变化对患者的生存时间预测具有一定价值。Objective To investigate the role of quantitative contrast-enhanced ultrasound(CEUS) parameters in predicting the overall survival(OS) of patients with unresectable pancreatic cancer treated with pulsed wave high intensity focused ultrasound(pHIFU).Method From February, 2020 to March, 2021, patients with unresectable pancreatic cancer who were treated with pHIFU in Beijing Friendship Hospital, Capital Medical University. The age, sex, stage, tumor volume, treatment energy, survival time and quantitative parameters of CEUS were recorded. The quantitative parameters in this study include rise intensity(RI), rise time(RT) and raise rate(Raise R). And the role of quantitative parameters in predicting patients’ OS were statistically analyzed. Result A total of 19 patients were enrolled. The median OS was 184d. Kaplan-Meier survival analysis showed that the patients who had increased relative Raise R after treatment had a better OS than those who decreased(P=0.027), and the median survival time was 301d and 114d respectively. Conclusion After pHIFU treatment, the changes of quantitative parameter in CEUS had a certain value in predicting the survival time of patients with unresectable pancreatic cancer.

关 键 词：胰腺癌 脉冲波高强度聚焦超声 生存时间 超声造影 

分 类 号：R445.1[医药卫生—影像医学与核医学]