黄连解毒汤联合低热量饮食对新诊断肥胖2型糖尿病血糖及胰岛素分泌影响的研究  

Effect of Huanglian Jiedu Decoction(黄连解毒汤)Combined with Low Calorie Diet on Blood Glucose and Insulin Secretion in Newly Diagnosed Obese Patients with Type 2 Diabetes

作　　者：符绩军 刘志勇 胡敏 张德杰 FU Jijun;LIU Zhiyong;HU Min;ZHANG Dejie(Department of Geriatrics,928 Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army,Haikou 571100,Hainan,China)

机构地区：[1]中国人民解放军联勤保障部队第九二八医院,海南海口571100

出　　处：《中华中医药学刊》2022年第12期143-145,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：中华医学会临床医学科研专项(192605935676332)。

摘　　要：目的观察黄连解毒汤联合低热量饮食对新诊断肥胖2型糖尿病患者血糖及胰岛素分泌影响。方法选取医院2021年1月—10月新诊断肥胖2型糖尿病患者196例为研究对象,依据随机数字表法均分为对照组和观察组各98例,对照组采用利拉鲁肽皮下注射用药联合低热量饮食干预,观察组在对照组的基础上增加黄连解毒汤治疗。比较两组患者的肥胖指标,血糖水平,胰岛素分泌功能,不良反应发生情况。结果治疗前两组患者的一般资料、肥胖指标,血糖水平、胰岛素分泌情况差异均无统计学意义(P>0.05),具有临床可比性。治疗后两组体质量、体质指数、体脂率显著下降,观察组降低更为明显,与对照组比较组间差异有统计学意义(P<0.05)。治疗后两组患者的空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖(2 hours postprandial blood glucose,2 h PG)、糖化血红蛋白(glycosylated hemoglobin,HbAlc)均显著降低,且观察组FPG及2 h PG显著低于对照组(P<0.05),但两组HbAlc水平差异无统计学意义(P>0.05)。治疗后两组空腹胰岛素(fasting insulin,FINS)、胰岛素抵抗指数(homeostasis model assessment insulinresistance,HOMA-IR)降低,胰岛素分泌指数(homeostasis model assessmentβ,HOMA-β)升高,观察组变化更为明显,与对照组比较组间差异有统计学意义(P<0.05)。观察组、对照组的不良反应发生率分别为9.2%(9/98)、6.1%(6/98),组间差异无统计学意义(P>0.05),不良反应均较轻微、可自行缓解。结论黄连解毒汤联合低热量饮食治疗新诊断肥胖2型糖尿病患者具有肯定的临床效果,能够改善患者的肥胖情况、有效控制血糖水平、改善胰岛素分泌功能,可以作为安全有效的治疗方案。Objective To observe the effect of Huanglian Jiedu Decoction(黄连解毒汤)combined with low calorie diet on blood glucose and insulin secretion in newly diagnosed obese patients with type 2 diabetes.Methods A total of 196 cases of newly diagnosed obese patients with type 2 diabetes in the hospital from January to October 2021 were selected and divided into two groups according to the random number table method,each with 98 patients.The control group was treated with Liraglutide subcutaneously combined with low calorie diet intervention and the observation group added Huanglian Jiedu Decoction.The obesity indicators,blood glucose levels,insulin secretion and adverse reactions of two groups were compared.Results There were no significant differences in general information,obesity indicators,blood glucose levels or insulin secretion between two groups before treatment(P>0.05)and they were clinically comparable.After treatment,the body weight,body mass index and body fat rate of two groups decreased significantly,the reduction in the observation group was more significant and the differences were statistically significant compared with those of the control group(P<0.05).After treatment,the fasting blood glucose(FPG)and 2-hour postprandial blood glucose(2 hPG)and glycated hemoglobin(HbAlc)were significantly reduced in both groups,and the levels of FPG and 2 hPG in the observation group were significantly lower than those in the control group(P<0.05),but there was no significant difference in HbAlc levels(P>0.05).After treatment,the levels of fasting insulin(FINS)and insulin resistance index(HOMA-IR)decreased and the insulin secretion index(HOMA-β)increased in two groups.The changes in the observation group were more significant and the differences between two groups were statistically significant compared with those of the control group(P<0.05).The incidence rates of adverse reactions in the observation group and the control group were 9.2%(9/98)and 6.1%(6/98)and there was no significant difference between two gro

关 键 词：肥胖 2型糖尿病 新诊断 黄连解毒汤 低热量饮食 血糖 胰岛素 

分 类 号：R259.871[医药卫生—中西医结合]