祛风除湿汤治疗乳房湿疹疗效观察及对EASI、DQOLS评分的影响  

Effect of Qufeng Chushi Decoction(祛风除湿汤)on Breast Eczema and Its Influence on EASI and DQOLS Scores

作　　者：张永岭 郭芳芳 刘国旗[1] ZHANG Yongling;Guo Fangfang;LIU Guoqi(Yellow River Sanmenxia Hospital,Sanmenxia 472000,Henan,China)

机构地区：[1]黄河三门峡医院,河南三门峡472000

出　　处：《中华中医药学刊》2022年第12期235-239,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：河南省科技计划(1724410059)。

摘　　要：目的探讨祛风除湿汤治疗乳房湿疹的疗效观察及对湿疹面积及严重程度指数(eczema area and severity index,EASI)、皮肤病生活质量量表(dermatology quality of life scales,DQOLS)评分的影响。方法选取2018年10月—2020年10月医院收治的哺乳期乳房湿疹患者108例,随机分为研究组(58例)和对照组(50例)两组。两组患者均接受一般治疗,另给予对照组西药治疗;研究组在对照组基础上加用祛风除湿汤内服外敷。比较两组中医证候积分、临床疗效、炎症因子指标、EASI评分、DQOLS评分和安全性。结果治疗前两组乳头、乳晕肿胀瘙痒、潮湿渗液、皮损、胸胁疼痛、少食便溏、情志不畅以及多太息等证候积分差异无统计学意义(P>0.05);治疗后,两组证候积分均降低(P<0.05),且相比于对照组,研究组更低(P<0.05)。治疗后,研究组痊愈14例(24.14%),显效17例(29.31%),好转23例(39.66%),无效4例(6.90%),对照组痊愈10例(20.00%),显效13例(26.00%),好转16例(32.00%),无效11例(22.00%),研究组总有效率92.00%高于对照组72.22%(P<0.05)。治疗前两组白介素(interleukin,IL)-2、IL-4及肿瘤坏死因子(tumor necrosis factor,TNF)-α指标差异均无统计学意义(P>0.05);研究组治疗后IL-2指标为(26.75±3.15)ng/L,低于治疗前[(60.45±6.38)ng/L](P<0.05),也低于对照组治疗后[(40.24±4.17)ng/L](P<0.05);研究组治疗后IL-4指标为(40.12±5.63)ng/L,低于治疗前[(78.91±12.62)ng/L](P<0.05),也低于对照组治疗后[(49.28±6.81)ng/L](P<0.05);研究组治疗后TNF-α指标为(38.16±3.97)ng/L,低于治疗前[(51.48±6.92)ng/L](P<0.05),也低于对照组治疗后[(43.10±4.65)ng/L](P<0.05)。治疗前研究组EASI评分[(3.48±1.02)分]与对照组[(3.52±0.98)分]、DQOLS评分[(46.62±6.38)分]与对照组[(46.41±5.93)分]差异均无统计学意义(P>0.05);治疗后,两组EASI评分均明显降低,且研究组[(0.95±0.19)分]低于对照组[(1.24±0.32)分](P<0.05)。两组DQOLS评分均明显升高(P<0.05),且�Objective To investigate the effect of Qufeng Chushi(祛风除湿汤)on breast eczema and its influence on eczema area and severity index(EASI)and dermatology quality of life scale(DQOLS)scores.Methods One hundred and eight patients with breast eczema in the hospital from October 2018 to October 2020 were enrolled and randomly divided into two groups.Both groups received routine treatment,based on this,the control group received western medicine,while the study group received western medicine combined with Qufeng Chushi Decoction both orally and externally.Then the TCM syndrome score,clinical efficacy,inflammatory indexes,EASI score,DQOLS score and safety were compared between the two groups.Results The scores of symptoms including swollen and itchy nipples and areolas,exudation,skin lesions,pain in the chest,poor appetite,loose stools,gloomy mood and deep sigh had no significant difference between the two groups at the baseline(P>0.05).The TCM syndrome score was decreased in both groups after treatment(P<0.05),and was significantly lower in the study group than that in the control group(P<0.05).After treatment,14 cases(24.14%)were cured,17 cases(29.31%)were significantly improved,23 cases(39.66%)were effective and 4 cases(6.90%)were ineffective in the study group,while 10 cases(20.00%)were cured,13 cases(26.00%)were significantly improved,16 cases(32.00%)were effective and 11 cases(22.00%)were ineffective in the control group.The total effective rate was 92.00% in the study group,which was significantly higher than 72.22% in the control group(P<0.05).The levels of interleukin-2(IL-2),IL-4 and tumor necrosis factor-α(TNF-α)demonstrated no significant difference between the two groups before treatment(P>0.05).The levels of IL-2,IL-4 and TNF-αin the study group were(60.45±6.38)ng/L,(78.91±12.62)ng/L and(51.48±6.92)ng/L at the baseline,and the levels of all three indicators were decreased after treatment(P<0.05).The levels of IL-2,IL-4 and TNF-αafter treatment were(26.75±3.15)ng/L,(40.12±5.63)ng/L and(38.16

关 键 词：湿疹面积及严重程度指数 乳房湿疹 祛风除湿汤 皮肤病生活质量 炎症因子 

分 类 号：R275.958.23[医药卫生—中西医结合]