怡情止泻汤联合美沙拉嗪治疗溃疡性结肠炎临床效果观察  

Clinical Effect of Yiqing Zhixie Decoction(怡情止泻汤)Combined with Mesalazine on Ulcerative Colitis

作　　者：付荣华[1] 郑勇[1] 郑春菊[1] FU Ronghua;ZHENG Yong;ZHENG Chunju(Huai'an Hospital of Traditional Chinese Medicine,Huai'an 223001,Jiangsu,China)

机构地区：[1]淮安市中医院,江苏淮安223001

出　　处：《中华中医药学刊》2022年第12期244-247,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏省中医药科技发展计划(YB2020075)。

摘　　要：目的观察怡情止泻汤联合美沙拉嗪治疗溃疡性结肠炎临床效果。方法将医院2020年6月—2022年3月收治的62例溃疡性结肠炎患者以随机数字表法平均分为两组,对照组(31例)采取美沙拉嗪肠溶片治疗,观察组(31例)在对照组治疗基础上与怡情止泻汤结合进行治疗,数据观察:疗效与结肠镜下黏膜病变积分变化、中医证候积分(腹痛腹泻、食少腹胀、胸胁胀闷、喜好叹息、嗳气不爽等)变化、二胺氧化酶(diamine oxidase,DAO)及内毒素(endotoxin,ET)、D-乳酸等肠黏膜屏障功能指标变化、血清白介素-10(interleukin-10,IL-10)及白介素-33(interleukin-33,IL-33)、肿瘤坏死因子α(tumor necrosis factorα,TNF-α)变化、肠道菌群结构变化情况及生活质量量表评分(Generic Quality of Life Inventory-74,GQOLI-74)变化、症状(腹痛、发热、腹泻、黏液脓血便等)改善时间、不良反应。结果观察组治疗总有效率(90.32%)高于对照组(67.74%)(P<0.05);两组患者治疗前结肠镜下黏膜病变积分、中医证候积分(腹痛腹泻、食少腹胀、胸胁胀闷、喜好叹息、嗳气不爽等)、DAO、ET、D-乳酸、IL-10、IL-33、TNF-α、肠道菌群结构、GQOLI-74等指标比较,P>0.05,各组患者治疗后结肠镜下黏膜病变积分、中医证候积分(腹痛腹泻、食少腹胀、胸胁胀闷、喜好叹息、嗳气不爽等)、DAO、ET、D-乳酸、IL-10、IL-33、TNF-α、肠道菌群结构、GQOLI-74等指标均改善,观察组治疗后结肠镜下黏膜病变积分、中医证候积分(腹痛腹泻、食少腹胀、胸胁胀闷、喜好叹息、嗳气不爽等)、DAO、ET、D-乳酸、IL-10、IL-33、TNF-α、肠道菌群结构、GQOLI-74等指标优于对照组(P<0.05);观察组症状(腹痛、发热及腹泻、黏液脓血便等)改善时间均比对照组患者更短(P<0.05);观察组不良反应率与对照组均较低(P>0.05)。结论怡情止泻汤联合美沙拉嗪治疗溃疡性结肠炎临床效果显著,且安全可靠。Objective To observe the clinical effect of Yiqing Zhixie Decoction(怡情止泻汤)combined with vidrizumab in the treatment of ulcerative colitis.Methods A total of 62 patients with ulcerative colitis admitted to the hospital from June 2020 to March 2022 were divided into two groups by random number table method.The control group(31 cases)was treated with mesalazine enteric-coated tablets,and the observation group(31 cases)was treated with Yiqing Zhixie Decoction on the basis of the treatment of the control group.Data observation:The curative effect with colonoscopy mucosal lesions under change,traditional Chinese medicine syndrome scores(abdominal pain,diarrhea,abdominal distension due to lack of food,chest and flank distension,preference for sighing,belching,etc.),diamine oxidase(DAO)and endotoxin(ET),D-lactic acid and other intestinal mucous membrane barrier function indexes,serum levels of interleukin-10(IL-10),interleukin-33(IL-33)and tumor necrosis factorα(TNF-α),structural changes of intestinal flora,changes of quality of life Scale(GQOLI-74),improvement time of symptoms(abdominal pain,fever,diarrhea,mucus,pus,blood stool,etc.)and adverse reactions were compared.Results The total effective rate of the observation group(90.32%)was higher than that of the control group(67.74%)(P<0.05).Comparison of colonoscopic mucosal lesion score,traditional Chinese medicine syndrome scores(abdominal pain,diarrhea,abdominal distension due to lack of food,chest and flank distension,preference for sighing,belching,etc.),DAO,ET,D-lactic acid,IL-10,IL-33,TNF-α,intestinal microflora structure,GQOLI-74 and other indicators between two groups before treatment had no significance(P>0.05).After treatment,scores of mucosal lesions under colonoscopy,scores of traditional Chinese medicine syndromes(abdominal pain,diarrhea,abdominal distension due to lack of food,chest and flank distension,preference for sighing,belching,etc.),DAO,ET,D-lactic acid,IL-10,IL-33,TNF-α,intestinal flora structure,GQOLI-74 and other indicators were imp

关 键 词：溃疡性结肠炎 怡情止泻汤 美沙拉嗪 疗效 中医症状积分 不良反应 

分 类 号：R259.746.2[医药卫生—中西医结合]