疏肝理气汤加减联合“心身同治”法对乳腺癌术后血清嗜铬粒蛋白A及疾病进展时间的影响  

Effect of Shugan Liqi Decoction(疏肝理气汤)Combined with“Simultaneous Treatment of Body and Mind”on Serum Chromogranin A and Disease Progression Time in Patients with Breast Cancer

作　　者：潘建锋 来玉凤 裴静波 邹媛媛[1] PAN Jianfeng;LAI Yufeng;PEI Jingbo;ZOU Yuanyuan(Jiangnan Hospital,Zhejiang Chinese Medical University,Hangzhou 311201,Zhejiang,China)

机构地区：[1]浙江中医药大学附属江南医院,浙江杭州311201

出　　处：《中华中医药学刊》2022年第12期251-254,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划(2021ZB241)。

摘　　要：目的探究舒肝理气汤辨证加减施治联合“心身同治”法对乳腺癌患者术后血清嗜铬粒蛋白A及疾病进展时间的影响。方法选取医院2016年1月—2021年1月收治的100例接受手术治疗的乳腺癌患者,按照数字随机分组法将其分为研究组50例,对照组50例。对照组患者给予常规西药治疗,研究组患者给予中药汤剂舒肝理气汤辨证加减方结合“心身同治”法治疗,对比两组患者治疗前后血清嗜铬粒蛋白A(chromogranin A,CGA)、C-反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factors-α,TNF-α)指标改善情况;对比两组患者治疗前后中医证候积分改善情况;对比两组患者治疗前后抑郁症状严重程度量表(patient health questionnaire-9,PHQ-9)和广泛性焦虑量表(generalized anxiety disorder-7,GAD-7)评分;对比两组患者中位肿瘤进展时间(time to progress,TTP);对比两组患者临床治疗疗效。结果治疗后研究组患者CGA、CRP、Tan-α指标明显低于对照组患者,对比差异具有统计学意义(P<0.05);治疗后研究组患者恶心呕吐、吞咽困难、腹胀腹痛、腹泻便血等中医证候积分明显低于对照组患者,对比差异具有统计学意义(P<0.05);治疗后研究组患者HQ-9、GAD-7评分明显低于对照组患者,对比差异具有统计学意义(P<0.05);研究组患者的中位TTP为12.3个月(95%CI:8.118~13.672个月),对照组患者的中位TTP为13.1个月(95%CI:9.015~13.972个月),差异具有统计学意义(P<0.05);研究组患者临床治疗总有效率(96.00%)明显高于对照组患者(84.00%),对比差异具有统计学意义(P<0.05)。讨论舒肝理气汤辨证加减施治联合“心身同治”法可显著改善乳腺癌患者术后临床症状,有效降低患者术后焦虑抑郁评分,改善患者疾病进展时间。Objective To explore the effect of Shugan Liqi Decoction(疏肝理气汤)combined with“simultaneous treatment of body and mind”on serum chromogranin A and disease progression time of breast cancer patients after operation.Methods A total of 100 breast cancer patients admitted to the Department of Oncology,Hospital from January 2016 to January 2021 were selected and randomly divided into study group(50 cases)and control group(50 cases)according to the numerical random grouping method.The control group was treated with conventional western medicine,while the study group was treated with Shugan Liqi Decoction combined with“simultaneous treatment of body and mind”.The serum levels of chromogranin A(CGA),C-reactive protein(CRP)and tumor necrosis factor(TNF-α)were compared between the two groups before and after treatment.The improvement of TCM syndrome score before and after treatment was compared between the two groups.The scores of Patient Health Questionnaire 9(PHQ-9)and Generalized Anxiety Disorder 7(GAD-7)before and after treatment were compared between the two groups.The time to progress(TTP)was compared between two groups.The clinical therapeutic effect was compared between the two groups.Results After treatment,the levels of CGA,CRP and TNF-α in the study group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of TCM syndromes such as nausea and vomiting,dysphagia,abdominal distension and abdominal pain,diarrhea and hematococcal blood in the study group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,PHQ-9 and GAD-7 scores in the study group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).The TTP was 12.3 months(95%CI:8.118~13.672 months)in the study group and 13.1 months(95%CI:9.015-13.972 months)in the control group,and the difference was statistically signifi

关 键 词：心身同治 乳腺癌 进展时间 中医证候积分 

分 类 号：R273.379[医药卫生—中西医结合]