人型支原体感染与中国育龄妇女不孕症相关性的Meta分析  

A Meta-analysis on the association between Mycoplasma hominis infection and infertility in Chinese women of childbearing age

作　　者：赵雅琪 宋学龙 覃金艳 宣岩 晏涛 王蓓[1] ZHAO Ya-qi;SONG Xue-long;QIN Jin-yan;XUAN Yan;YAN Tao;WANG Bei(School of PublicHealth,SoutheastUniversity,Nanjing,Jiangsu 210009,China;不详)

机构地区：[1]东南大学公共卫生学院流行病与卫生统计学系,环境医学工程教育部重点实验室,江苏南京210009

出　　处：《中国预防医学杂志》2022年第11期827-834,共8页Chinese Preventive Medicine

基　　金：国家自然科学基金(81872634);东南大学国家级创新训练项目(202110286147)。

摘　　要：目的 系统评价人型支原体感染与女性不孕症之间的关系。方法 检索中国知网、万方、WOS、Sinomed、PubMed等国内外文献数据库,搜集有关人型支原体感染与我国育龄女性不孕的病例-对照研究。检索时间从建立数据库至2022年1月。由2名研究员分别独立筛选文献、提取资料并评价纳入研究的质量后,采用RevMan5.4软件进行Meta分析,异质性检验中若I2≤50%采用固定效应模型,相反则采用随机效应模型,并通过亚组分析,分析异质性来源。结果 本文共纳入44篇研究文献,样本量合计51 373例,观察组与对照组人型支原体感染比较,差异有统计学意义(OR=2.86,95%CI:2.24~3.65,P<0.01),亚组分析结果显示,不同年龄阶段异质性下降,地区结果变化不大,发表年份中2012年前的异质性较总体下降,2012年后结果变化不大,提示研究人群年龄可能是异质性来源。结论 人型支原体感染与育龄女性不孕相关,临床上需重视对备孕人群进行人型支原体筛查,预防育龄女性不孕症的发生发展,提高女性生殖道健康水平。Objective To systematically evaluate the relationship between Mycoplasma hominis(Mh) infection and female infertility. Methods Literatures related to case-control study on Mh infection and infertility in Chinese women of childbearing age were obtained by searching CNKI, Wanfang, WOS, Sinomed, PubMed and other domestic and foreign literature databases up to January 2022.Two researchers independently screened literatures, extracted data, and evaluated the risk of bias of included studies.RevMan5.4 software was used for meta-analysis.In heterogeneity test, fixed effect model was applied if I~2≤50%, otherwise, random effect model was used. Results A total of 44 literatures were included in this mete analysis, with a total sample size of 51 373 cases.The difference in Mh infection between the infertility group and the control group was statistically significant(OR=2.86, 95%CI: 2.24-3.65, P<0.01).The results of subgroup analysis showed that the heterogeneity decreased significantly at different age, while it remained relative stable in different region.The heterogeneity before 2012 was significantly lower than that after 2012, suggesting that the age of the study population might be the source of heterogeneity. Conclusions Mh infection is related to infertility in women of childbearing age.It is necessary to conduct Mh screening among women who plan to have babies in order to decrease the possibility of infertility in women of childbearing age.

关 键 词：人型支原体 女性不孕症 META分析 病例-对照研究 

分 类 号：R183[医药卫生—流行病学]