从科研走向临床:磁共振成像技术在神经退行性疾病中的应用潜力巨大  

From research to clinic:The huge potential about application of magnetic resonance imaging in neurodegenerative disease

作　　者：田瑶天 李春媚[1,2] 陈敏 TIAN Yaotian;LI Chunmei;CHEN Min(Department of Radiology,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China;Graduate School of Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]北京医院放射科,国家老年医学中心,中国医学科学院老年医学研究院,北京100730 [2]中国医学科学院北京协和医学院研究生院,北京100730

出　　处：《磁共振成像》2023年第1期1-5,19,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:82071891、81771826)。

摘　　要：MRI技术近年来不断取得新的发展,可以为脑组织的形态学结构、血流灌注、白质及轴突微结构、神经元活动及多种代谢物负荷等提供丰富的信息,因此在神经退行性疾病中的应用也越来越广泛。本述评对MRI技术在神经退行性疾病中的应用及研究现状进行了点评,强调了MRI技术对神经退行性疾病潜在病理生理机制的揭示及其在疾病诊断及鉴别诊断、病情进展评估及预测中的作用,同时也指出这些技术在由科研向临床应用转化方面面临着的诸多挑战,并对MRI技术在神经退行性疾病中的未来发展方向作出展望。The continuous advances in MRI technology can provide new insights into brain about morphological structure,perfusion,white matter and axonal microstructure,neuronal activity and multiple metabolite loads,which has led to its widely implementation in neurodegenerative diseases.This paper reviewed the application and research status of MRI technology in neurodegenerative diseases,delineated its potential pathophysiological mechanisms,emphasized its role in the diagnosis,differentiation and progress prediction of neurodegenerative diseases.Meanwhile,it pointed out the challenges these technologies faced in transforming from scientific research to clinical application,and given the prospect of future development of MRI technology in neurodegenerative diseases.

关 键 词：神经退行性疾病 阿尔茨海默病 帕金森病 多系统萎缩 肌萎缩性侧索硬化症 磁共振成像 结构磁共振成像 动脉自旋标记 扩散张量成像 定量磁敏感图 血氧水平依赖 化学交换饱和转移 磁共振波谱 研究进展 

分 类 号：R445.2[医药卫生—影像医学与核医学] R741[医药卫生—诊断学]