化学交换饱和转移成像在神经退行性疾病中的研究进展  

Research progress of chemical exchange saturation transfer magnetic resonance imaging in neurodegenerative disease

作　　者：田瑶天 李春媚[1,2] 陈敏 TIAN Yaotian;LI Chunmei;CHEN Min(Department of Radiology,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China;Graduate School of Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]北京医院放射科,国家老年医学中心,中国医学科学院老年医学研究院,北京100730 [2]中国医学科学院北京协和医学院研究生院,北京100730

出　　处：《磁共振成像》2023年第1期32-35,47,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:82071891、81771826)。

摘　　要：化学交换饱和转移(chemical exchange saturation transfer,CEST)成像是基于化学交换及磁化转移所发展出来的一种新型成像方法,可以选择性饱和特定代谢物中的可交换质子并向自由水进行磁化转移,从而通过检测自由水的信号强度间接反映特定代谢物的信号强度。基于此,CEST可以无需对比剂或放射性示踪剂的参与即可实现在体低浓度代谢物的无创检测,因而在中枢神经系统疾病中得到大量应用。神经退行性疾病是中枢神经系统疾病的重要组成部分。本文将主要阐述CEST成像在神经退行性疾病中的应用现状及进展。Chemical exchange saturation transfer(CEST)imaging is a new imaging method developed based on chemical exchange and magnetization transfer technology,which can selectively saturate exchangeable protons in specific metabolites and transfer magnetization to free water.Thus,the signal intensity of specific metabolites can be indirectly reflected by detecting the signal intensity of free water.Based on this,CEST can achieve in vivo non-invasive detection of low concentration of metabolites without the involvement of contrast agents or radioactive tracers,so it has been widely used in central nervous system diseases.Neurodegenerative diseases are an important part of central nervous system diseases.This review will focus on the application and progress of CEST imaging in neurodegenerative diseases.

关 键 词：神经退行性疾病 阿尔茨海默病 帕金森病 亨廷顿病 肌萎缩性侧索硬化症 多发性硬化 磁共振成像 化学交换饱和转移成像 酰胺质子转移成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R741[医药卫生—诊断学]