扩散张量成像对新生儿急性胆红素脑病神经核团及脑白质纤维的分析研究  

Study of cerebral nuclei and white matter fibers in neonatal acute bilirubin encephalopathy based on diffusion tensor imaging

作　　者：牛劲 闫瑞芳[1] 殷慧佳 任继鹏[1] 岳征 谢北辰 韩东明[1] NIU Jin;YAN Ruifang;YIN Huijia;REN Jipeng;YUE Zheng;XIE Beichen;HAN Dongming(Department of Magnetic Resonance,the First Affiliated Hospital of Xinxiang Medical College,Xinxiang 453100,China)

机构地区：[1]新乡医学院第一附属医院磁共振科,新乡453100

出　　处：《磁共振成像》2023年第1期67-71,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：河南省医学科技攻关计划项目(编号:LHGJ20200519)。

摘　　要：目的探讨扩散张量成像(diffusion tensor imaging,DTI)对急性胆红素脑病(acute bilirubin encephalopathy,ABE神经核团及脑白质纤维束的研究价值。材料与方法选取30例ABE足月新生儿作为病变组,对照组选取30例正常足月新生儿,行常规MRI和DTI检查。测量双侧额叶运动皮层、额叶深部白质、侧脑室体上方白质、丘脑腹侧核、苍白球、内囊后肢、胼胝体压部、丘脑底核、红核/黑质、脑桥核、海马、延髓核及小脑齿状核DTI参数,包括平均扩散系数(average diffusion coefficient,ADC)、各向异性分数(fractional anisotropy,FA)及各向同性(isotropy,Iso)值,分别进行统计学分析。结果与对照组相比,病变组双侧额叶运动皮层、内囊后肢、齿状核ADC、Iso值下降,FA值升高(P<0.05);病变组双侧脑室体上方白质、苍白球、胼胝体压部、红核/黑质、脑桥核、海马Iso值下降(P<0.05)。两组相比双侧额叶深部白质、丘脑腹侧核、丘脑底核延髓核ADC、FA和Iso值差异均无统计学意义(P>0.05)。结论DTI提示了ABE可能同时存在神经核团及脑白质纤维损伤。Objective:To investigate the value of diffusion tensor imaging(DTI)in the study of cerebral nuclei and white matter fibers in acute bilirubin encephalopathy(ABE).Materials and Methods:Thirty full-term neonates with ABE were selected as the lesion group,and 30 normal full-term neonates were selected as the control group.All of them were examined by conventional MRI and DTI.The average diffusion coefficient(ADC),fractional anisotropy(FA)and isotropy(Iso)values of bilateral frontal lobe motor cortex,deep frontal lobe white matter,white matter above lateral ventricle,ventral thalamic nucleus,globus pallidus,posterior limb of internal capsule,splenium corporis callosi,subthalamic nucleus,red nucleus/substantia nigra,pontine nucleus,hippocampus,medulla oblongata and cerebellar dentate nucleus were measured and statistically analyzed respectively.Results:Compared with the control group,ADC and Iso values were lower and FA values were higher in the bilateral frontal lobe motor cortex,posterior limb of internal capsule and dentate nucleus of the lesion group(P<0.05).And Iso values were lower in the bilateral white matter above bilateral lateral ventricle,globus pallidus,splenium corporis callosi,red nucleus/substantia nigra,pontine nucleus and hippocampus of the lesion group(P<0.05).There were no significant statistical difference in ADC,FA and Iso values in the bilateral frontal lobes deep white matter,ventral thalamic nucleus,subthalamic nucleus and medulla oblongata(P>0.05).Conclusions:DTI suggests that the injury of cerebral nuclei and white matter fibers in ABE.

关 键 词：胆红素脑病 新生儿 神经通路 扩散张量成像 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R722.17[医药卫生—诊断学]