水-甘油通道蛋白与砷代谢对人类疾病的影响  

Effects of aquaglyceroporins and arsenic metabolism on human diseases

作　　者：王晓臻 王晓雯 王乙 王倩倩 曹亦菲[1] WANG Xiaozhen;WANG Xiaowen;WANG Yi;WANG Qianqian;CAO Yifei(School of Public Health,Hangzhou Normal University,Hangzhou 311121,China)

机构地区：[1]杭州师范大学公共卫生学院,浙江杭州311121

出　　处：《健康研究》2022年第6期681-685,共5页Health Research

基　　金：浙江省自然科学基金基础公益项目(LY19H260002)。

摘　　要：水-甘油通道蛋白家族(aquaglyceroporins, AQPs)在砷进出机体细胞中起着重要作用。AQPs可以促进砷转运到细胞中,有利于砷剂对疾病的治疗;也可以促进砷的外排,构成解毒通路。文章就目前AQPs与砷代谢的相关研究和作用机制进行综述。Aquaglyceroporins(AQPs) play an important role in arsenic ingress and egress into cells. AQPs can promote the transport of arsenic into cells, which is beneficial to the treatment of diseases by arsenic;It can also promote the discharge of arsenic, forming a detoxification pathway. This paper reviews the current research and mechanism of AQPs and arsenic metabolism.

关 键 词：水甘油通道蛋白 砷 P38丝裂原活化蛋白激酶 

分 类 号：R12[医药卫生—环境卫生学]