GnRHa联合LNG-IUS方案治疗子宫腺肌病的临床效果  

Clinical effect of GnRHa combined with LNG-IUS regimen in the treatment of adenomyosis

作　　者：喻凌云 黄小琴[2] 申恒春 YU Lingyun;HUANG Xiaoqin;SHEN Hengchun(Department of Obstetrics and Gynecology,Affiliated Hospital of Southwest Medical University,Sichuan Province,Luzhou646000,China;Department of Obstetrics and Gynecology,Neijiang First People’s Hospital,Sichuan Province,Neijiang641000,China)

机构地区：[1]西南医科大学附属医院妇产科,四川泸州646000 [2]四川省内江市第一人民医院妇产科,四川内江641000

出　　处：《中国医药导报》2022年第36期109-112,共4页China Medical Herald

基　　金：四川省科技厅重点研发项目(2019YFS0444)。

摘　　要：目的探究促性腺激素释放激素激动剂(Gn RHa)与左炔诺孕酮宫内释放系统(LNG-IUS)联合治疗子宫腺肌病的临床效果。方法选择2018年5月至2021年1月四川省内江市第一人民医院收治的子宫腺肌病患者90例。采用随机数字表法将其分为两组,每组45例。试验组给予Gn RHa与LNG-IUS联合治疗,对照组给予单一Gn RHa治疗。比较两组治疗前、治疗6个月后、治疗1年后视觉模拟评分法(VAS)、月经量评分、子宫体积、子宫内膜厚度及糖类抗原-125(CA125)水平,观察不良反应发生情况。结果治疗6个月及1年后,两组VAS评分、子宫体积、子宫内膜厚度、月经量评分、CA125小于治疗前,差异有统计学意义(P<0.05)。治疗1年后,试验组VAS评分低于治疗6个月后;对照组VAS评分、子宫内膜厚度、CA125小于治疗6个月后,差异有统计学意义(P<0.05)。治疗6个月后,试验组VAS评分、子宫体积、子宫内膜厚度、月经量评分、CA125小于对照组,差异有统计学意义(P<0.05);治疗1年后,试验组VAS评分、子宫体积、月经量评分、CA125小于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论Gn RHa与LNG-IUS联合治疗子宫腺肌病效果较佳,具有优越的应用前景。Objective To investigate the clinical effect of gonadotropin-releasing hormone agonist(Gn RHa)combined with levonorgestrel intrauterine release system(LNG-IUS)in the treatment of adenomyosis.Methods A total of 90 patients with adenomyosis admitted to Neijiang First People’s Hospital of Sichuan Province from May 2018 to January 2021 were selected.They were divided into two groups by random number table method,with 45 cases in each group.The experimental group was given Gn RHa and LNG-IUS combined treatment,and the control group was given single Gn RHa treatment.Visual analogue scale(VAS),menstrual volume score,uterine volume,endometrial thickness,and carbohydrate antigen-125(CA125)level were compared between two groups before treatment,six months after treatment,and one year after treatment,and the occurrence of adverse reactions was observed.Results Six months and one year after treatment,VAS score,uterine volume,endometrial thickness,menstrual volume score,and CA125 between two groups were less than those before treatment,and the differences were statistically significant(P<0.05).One year after treatment,VAS score of the experimental group was lower than that six months after treatment;VAS score,endometrial thickness,and CA125 of control group were lower than those six months after treatment,and the differences were statistically significant(P<0.05).Six months after treatment,VAS score,uterine volume,endometrial thickness,menstrual volume score,and CA125 of experimental group were lower than those of control group,and the differences were statistically significant(P<0.05).One year after treatment,VAS score,uterine volume,menstrual volume score,and CA125 of experimental group were lower than those of control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P>0.05).Conclusion The combination of Gn RHa and LNG-IUS in the treatment of adenomyosis has a better curative effect and a superior application

关 键 词：促性腺激素释放激素激动剂 左炔诺孕酮 宫内缓释 子宫腺肌病 

分 类 号：R711.5[医药卫生—妇产科学]