醋酸甲羟孕酮联合刮宫术治疗围绝经期异常子宫出血的临床效果分析  

Clinical analysis of medroxyprogesterone acetate combined with curettage in the treatment of perimenopausal abnormal uterine bleeding

作　　者：刘玉飞 Liu Yufei(Department of Gynecology,The First People's Hospital of Longnan,Longnan 746000,China)

机构地区：[1]陇南市第一人民医院妇科,甘肃陇南746000

出　　处：《实用妇科内分泌电子杂志》2022年第20期48-50,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的 探究围绝经期异常子宫出血患者使用醋酸甲羟孕酮联合刮宫术进行治疗的临床效果。方法 选取102例围绝经期异常子宫出血患者,利用随机数字表法将其分为对照组与试验组,每组51例。对照组采用地屈孕酮治疗,试验组采用醋酸甲羟孕酮联合刮宫术治疗。比较两组患者治疗效果和不良反应发生情况。结果 试验组控制出血时间、完全出血时间均短于对照组,差异有统计学意义(P<0.05)。治疗前,两组子宫内膜厚度、雌二醇、卵泡刺激素、促黄体生成素及孕酮水平比较,差异无统计学意义(P>0.05);治疗后,试验组子宫内膜厚度薄于对照组,雌二醇、卵泡刺激素、促黄体生成素及孕酮水平均明显低于对照组,差异有统计学意义(P<0.05)。试验组患者不良反应发生率11.76%低于对照组的54.90%,差异有统计学意义(P<0.05)。结论 醋酸甲羟孕酮联合刮宫术可以有效改善围绝经期异常子宫出血患者症状,可降低不良反应发生率,临床效果显著。Objective To investigate the clinical effect of medroxyprogesterone acetate combined with curettage in perimenopausal patients with abnormal uterine bleeding. Methods 102 patients with perimenopausal abnormal uterine bleeding were selected and divided into control group and experimental group by random number table method, with 51 cases in each group.The control group was treated with dydrogesterone and the experimental group was treated with medroxyprogesterone acetate combined with curettage. The therapeutic effect and the occurrence of adverse reactions were compared between the two groups.Results The control bleeding time and complete bleeding time of experimental group were shorter than those of control group, and the difference was statistically significant(P<0.05). Before treatment, there were no significant differences in endometrial thickness,estradiol, follicle-stimulating hormone, luteinizing hormone and progesterone levels between the two groups(P>0.05). After treatment, the endometrial thickness of experimental group was thinner than that of control group, and the levels of estradiol, follicle stimulating hormone, luteinizing hormone and progesterone were significantly lower than those of control group, the difference was statistically significant(P<0.05). The incidence of adverse reactions in experimental group was 11.76% lower than that in control group(54.90%), and the difference was statistically significant(P<0.05). Conclusion Medroxyprogesterone acetate combined with curettage can effectively improve the symptoms of abnormal uterine bleeding in perimenopausal period and reduce the incidence of adverse reactions, with significant clinical effect.

关 键 词：围绝经期异常子宫出血 醋酸甲羟孕酮 刮宫术 

分 类 号：R713.4[医药卫生—妇产科学]