脑血流量诊断非神经精神性系统性红斑狼疮  

Cerebral blood flow for diagnosis of non-neuropsychiatric systemic lupus erythematosus

作　　者：张鹏 李晓露 周文苏 夏建国[2] 孙中茹 邹红梅[3] ZHANG Peng;LI Xiaolu;ZHOU Wensu;XIA Jianguo;SUN Zhongru;ZOU Hongmei(Graduate School of Dalian Medical University,Dalian 116044,China;Department of Imaging,Taizhou People's Hospital,Taizhou 225300,China;Department of Rheumatology and Immunology,Taizhou People's Hospital,Taizhou 225300,China)

机构地区：[1]大连医科大学研究生院,辽宁大连116044 [2]泰州市人民医院影像科,江苏泰州225300 [3]泰州市人民医院风湿免疫科,江苏泰州225300

出　　处：《中国医学影像技术》2023年第1期22-26,共5页Chinese Journal of Medical Imaging Technology

基　　金：江苏省卫生健康委科研课题(H2018093);江苏省第五期“333工程”科研项目(BRA2017175)。

摘　　要：目的观察脑血流量(CBF)诊断非神经精神性系统性红斑狼疮(non-NPSLE)的价值。方法前瞻性纳入26例non-NPSLE患者(SLE组)和26名健康志愿者(正常对照组),采集颅脑3D-T1W及动脉自旋标记(ASL)图像;观察组间CBF存在差异脑区,分析SLE组存在差异脑区CBF与临床资料的相关性,评估其诊断non-NPSLE的价值。结果相比正常对照组,SLE组左侧小脑_9及右侧舌回CBF均减少(P均<0.05)、左侧内侧和旁扣带回及左侧豆状核壳CBF增加(P均<0.05)。SLE组左侧豆状核壳、左侧内侧和旁扣带回CBF均与IgA呈正相关(r=0.582、0.499,P=0.002、0.010)。以0.84、0.66、1.50及1.24 ml/(100 g·min)为截断值,左侧小脑_9、右侧舌回、左侧内侧和旁扣带回及左侧豆状核壳CBF诊断non-NPSLE的曲线下面积分别为0.85、0.81、0.80及0.80。结论ASL所示CBF可用于诊断non-NPSLE。Objective To observe the value of cerebral blood flow(CBF)for diagnosis of non-neuropsychiatric systemic lupus erythematosus(non-NPSLE).Methods Twenty-six non-NPSLE patients(SLE group)and 26 healthy volunteers(normal control group)were prospectively enrolled.Brain 3D-T1W and arterial spin labeling(ASL)images were obtained to screen brain regions with different CBF between groups.The correlations of CBF in different brain regions with clinical data in SLE group were analyzed,and the value of CBF for diagnosing non-NPSLE was evaluated.Results Compared with control group,CBF of left cerebellum_9 and right tongue gyrus decreased,while of left medial and paraclasal gyrus and left lentiform nucleus shell increased in SLE group(all P<0.05).CBF of left cerebellum_9 and left medial and paraclasal gyrus of SLE group were positively correlated with IgA(r=0.582,0.499;P=0.002,0.010).Taken 0.84,0.66,1.50 and 1.24 ml/(100 g·min)as the best cut-off values of CBF of left cerebellum_9,right tongue gyrus,left medial and paraclasal gyrus and the left lentiform nucleus shell for diagnosing non-NPSLE,the area under the curve was 0.85,0.81,0.80 and 0.80,respectively.Conclusion CBF showed with ASL could be used to diagnose non-NPSLE.

关 键 词：红斑狼疮 系统性 脑血管循环 磁共振成像 

分 类 号：R593.241[医药卫生—内科学] R445.2[医药卫生—临床医学]