大黄及其活性成分抗炎作用及机制的研究进展  

Research progress on anti-inflammatory effects and mechanism of Rhei Radix et Rhizoma and its active components

作　　者：曹强[1] 郭亚菲 叶蕾蕾 张成园 寇仁博 郭玫[1,2] CAO Qiang;GUO Ya-fei;YE Lei-lei;ZHANG Cheng-yuan;KOU Ren-bo;GUO Mei(Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Key Laboratory of Chemistry and Quality for Traditional Chinese Medicine of Colleges of Gansu Province,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省高校中(藏)药化学与质量研究省级重点实验室,甘肃兰州730000

出　　处：《中草药》2022年第22期7285-7294,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然基金联合基金重点项目(U21A20412);甘肃省自然科学基金项目(21JR7RA558);甘肃省教育厅“双一流”科研重点项目(GSSYLXM-05);甘肃中医药大学研究生创新基金(2022CX86)。

摘　　要：大黄为蓼科植物掌叶大黄Rheum palmatum、唐古特大黄R. tanguticum或药用大黄R. officinale的干燥根和根茎,具有泻下攻积、清热泻火、凉血解毒、逐瘀通经、利湿退黄之功。近年来研究发现大黄及其活性成分大黄素、大黄酸、大黄酚、芦荟大黄素等具有良好的抗炎、解热镇痛、抗肿瘤等活性。对大黄及其活性成分在治疗急性胰腺炎、脓毒症、关节炎等炎症性疾病的作用及机制的研究进展进行综述,以期为其在防治炎症疾病中的深入研究及开发应用提供参考。Dahuang(Rhei Radix et Rhizoma, RRR) is the dry root and rhizome of the polygonum family plant Rheum palmatum, R.tanguticum or R. officinale, which has the functions of purgative accumulation, clearing away heat and fire, cooling blood and detoxifying, removing blood stasis and channeling meridian, excreting dampness and anti-icteric.In recent years, it has been found that RRR and its active components emodin, rhein, chrysophanol and aloe emodin have good anti-inflammatory, antipyretic,analgesic and antitumor activities. In this paper, the effects and mechanisms of RRR and its active components in the treatment of acute pancreatitis, sepsis, arthritis and other inflammatory diseases were reviewed, in order to provide a reference for the further research and development of its application in the prevention and treatment of inflammatory diseases.

关 键 词：大黄 抗炎 急性胰腺炎 脓毒症 关节炎 作用机制 大黄素 大黄酸 大黄酚 芦荟大黄素 

分 类 号：R28[医药卫生—中药学]