甜梦口服液联合舍曲林对改善脑功能减退患者认知功能、焦虑情绪及睡眠障碍的临床研究  

Clinical study of Tianmeng Oral Liquid combined with sertraline on improving cognitive function,anxiety and sleep disorders in patients with cerebral hypofunction

作　　者：刘佩佩[1] 刘小娟[1] 黄质诚 刘茹[1] 刘烨 LIU Pei-pei;LIU Xiao-juan;HUANG Zhi-cheng;LIU Ru;LIU Ye(Department of Psychology,Tianjin Occupational Diseases Precaution and Therapeutic Hospital,Tianjin 30011,China;Zhejiang Quhua Hospital,Quzhou 324004,China)

机构地区：[1]天津市职业病防治院心理科,天津300112 [2]浙江衢化医院,浙江衢州324004

出　　处：《中草药》2022年第21期6805-6809,共5页Chinese Traditional and Herbal Drugs

摘　　要：目的观察甜梦口服液联合舍曲林对改善脑功能减退患者认知功能、焦虑情绪及失眠的临床效果。方法选取2018年6月-2020年6月就诊于天津市职业病防治院的80例伴有焦虑情绪及睡眠障碍的脑功能减退患者,并随机将其分为试验组及对照组,每组各40例。试验组患者给予甜梦口服液联合舍曲林治疗,对照组患者仅口服舍曲林。比较治疗前后两组患者的认知功能的差异,以及焦虑情绪及睡眠障碍的改善情况。结果与治疗前比较,两组治疗后记忆力水平均得以提升(P<0.05),且治疗后试验组的各项目的评分都显著高于对照组(P<0.05)。与治疗前比较,两组治疗后各项睡眠质量评分均明显下降(P<0.05);治疗后,试验组患者的各项评分均显著低于对照组(P<0.05),试验组睡眠质量改善总有效率85%,明显高于对照组的60%(P<0.05)。治疗后,试验组情绪改善总有效率87.5%,明显高于对照组的55.0%(P<0.05)。结论对脑功能减退合并焦虑及失眠的患者,选用甜梦口服液联合舍曲林治疗比单用舍曲林治疗效果更佳,值得临床借鉴及推广。Objective To observe the clinical effect of Tianmeng Oral Liquid(甜梦口服液)combined with sertraline on improving cognitive function,anxiety and insomnia in patients with cerebral hypofunction.Methods A total of 80 patients with brain dysfunction accompanied by anxiety and sleep disorders who were treated in Tianjin Occupational Diseases Precaution and Therapeutic Hospital from June 2018 to June 2020 were selected and randomly divided into experimental group and control group,with 40 cases in each group.The experimental group was given Tianmeng Oral Liquid combined with sertraline,and the control group was given sertraline only.The differences in cognitive function and the improvement of anxiety and sleep disorders between the two groups before and after treatment were compared.Results Compared with pre-treatment period,the memory level of two groups was improved after treatment(P<0.05),and the scores of all items in the experimental group were significantly higher than those in the control group after treatment(P<0.05).Compared with before treatment,the scores of sleep quality in the two groups were significantly decreased after treatment(P<0.05),and the scores of the experimental group were significantly lower than those of the control group after treatment(P<0.05),and the total effective rate of sleep quality improvement in the experimental group was 85%,which was significantly higher than 60%in the control group(P<0.05).After treatment,the total effective rate of mood improvement in the experimental group was 87.5%,which was significantly higher than 55.0%in the control group,and the difference was significant(P<0.05).Conclusion For patients with cerebral hypofunction combined with anxiety and insomnia,the treatment effect of Tianmeng Oral Liquid combined with sertraline is better than sertraline alone,which is worthy of clinical reference and promotion.

关 键 词：甜梦口服液 舍曲林 脑功能减退 焦虑 睡眠障碍 

分 类 号：R285.42[医药卫生—中药学]