基于特征肽发现与应用的胶类中药质量控制  

Research progress on quality control of gelatinous traditional Chinese medicine based on discovery and application of specific peptides

作　　者：蔡朔 韩疏影[2] 夏浩然 闫郅烨 黄潇正 赵明 段金廒[1,2] 刘睿[1,2,3] CAI Shuo;HAN Shu-ying;XIA Hao-ran;YAN Zhi-ye;HUANG Xiao-zheng;ZHAO Ming;DUAN Jin-ao;LIURui(Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China;School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China;Jiangsu Key Laboratory of Research and Development in Marine Bio-resource Pharmaceutics,Nanjing 210023,China)

机构地区：[1]南京中医药大学江苏省中药资源产业化过程协同创新中心,中药资源产业化与方剂创新药物国家地方联合工程研究中心,江苏南京210023 [2]南京中医药大学药学院,江苏南京210023 [3]江苏省海洋药用生物资源研究与开发重点实验室,江苏南京210023

出　　处：《中草药》2022年第21期6888-6899,共12页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金面上项目(81973450);国家重点研发计划资助项目(2018YFC1706100);江苏省高校“青蓝工程”中青年学术带头人:江苏省第六期“333高层次人才培养工程”第三层次培养对象。

摘　　要：胶类中药源于动物的皮、角、甲等组织部位,经提取、浓缩、干燥而形成固体胶块,是极具特色的传统中药。近年来,胶类中药以其独特的滋补功效愈发受到消费者青睐,市场需求不断扩大。然而,胶类中药原料短缺、有效质量控制方法缺乏,导致伪劣胶类中药及其产品大行其道,严重影响行业声誉,危害人民健康安全。基于此,中药行业的学者们围绕胶类中药的质量控制研究不断创新突破,建立了多种高效、灵敏的胶类中药质量检测方法,以确保胶类中药的质量,促进行业健康发展。从胶类中药物质组成、质控方法、基于特征肽发现与应用的胶类中药质控方法等方面系统阐述了胶类中药的质控研究现状,为进一步构建和完善科学合理的质控体系提供参考,以期推动胶类中药及行业健康发展。Gelatinous traditional Chinese medicine(TCM),as a valuable characteristic TCM in China,is derived from the skin,horn,shell and other tissues of animals,and it forms solid blocks after extraction,concentration and drying.Recently,gelatinous TCMs have been increasingly favored by consumers because of its unique nourishing effect,and its market demand has been expanded continuously.However,the shortage of raw materials and the lack of effective quality control methods lead to the widespread use of fake and inferior gelatinous TCMs and their products,which seriously affect the reputation of the industry and endanger health and safety of people.Therefore,in order to ensure the quality of gelatinous TCMs and promote the healthy development of the industry,investigators have made continuous innovations and breakthroughs around the quality control research of gelatinous TCMs,and established a variety of efficient and sensitive quality detection methods.Research status of quality control of gelatinous TCMs was systematically reviewed from substance composition and quality control method based on discovery and application of characteristic peptide in this paper,in order to provide reference for further constructing and perfecting scientific and reasonable quality control system,and to promote the healthy development of gelatinous TCMs and industry.

关 键 词：胶类中药 特征肽 发现 应用 质量控制 生物标志物 

分 类 号：R284.191[医药卫生—中药学]