霍山石斛活性成分对肝脏疾病作用及其机制研究进展  

Research progress on effect and mechanism of Dendrobium huoshanense and its active components against liver diseases

作　　者：邓光辉 俞年军[1,2,3,4] 王妍妍 叶梦娟[1,2] 蔡肖 张晓倩 彭代银 DENG Guang-hui;YU Nian-jun;WANG Yan-yan;YE Meng-juan;CAI Xiao;ZHANG Xiao-qian;PENG Dai-yin(Anhui University of Chinses Medicine,Hefei 230012,China;Institute of Conservation and Development of Traditional Chinese Medicine Resources&Anhui Academy of Traditional Chinese Medicine,Hefei230012,China;MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials,Hefei230012,China;Key Laboratory of Traditional Chinese Medicine Research and Development of Anhui Province,Hefei 230012,China)

机构地区：[1]安徽中医药大学,安徽合肥230012 [2]安徽省中医药科学院中药资源保护与开发研究所,安徽合肥230012 [3]省部共建安徽道地中药材品质提升协同创新中心,安徽合肥230012 [4]中药研究与开发安徽省重点实验室,安徽合肥230012

出　　处：《中草药》2022年第21期6959-6967,共9页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金联合基金项目(U19A2009);安徽高校协同创新项目(GXXT-2019-043);省部共建安徽道地中药材品质提升协同创新中心项目(教科信厅函[2022]4号);安徽省教育厅项目(皖教秘科[2014]44号)。

摘　　要：霍山石斛Dendrobium huoshanense是我国的珍贵中药材,大量药理实验阐明霍山石斛在治疗肝脏疾病方面有显著疗效,从调节抗氧化水平、抑制炎症、抑制转化生长因子-β1和I、III胶原蛋白合成、减少肝脏脂质沉积等方面对肝脏疾病产生治疗作用。对霍山石斛化学成分和霍山石斛活性成分治疗肝脏疾病,如酒精性肝损伤、非酒精性肝损伤、化学性肝损伤、药物性肝损伤、肝纤维化的药理作用及其机制进行综述,为霍山石斛的资源利用和肝脏疾病的新药开发提供一定的理论基础。Dendrobium huoshanense is a precious traditional Chinese medicinal material in China.A large number of pharmacological experiments have demonstrated that D.huoshanense had significant curative effects in the treatment of liver diseases,from regulating antioxidation levels,inhibiting inflammation,inhibiting transforming growth factor-β1 and I,III collagen,reducing hepatic lipid deposition,and other aspects in the treatment of liver diseases.The article reviews the pharmacological effects and mechanisms of the chemical constituents and active ingredients of D.huoshanense in treating liver diseases,including alcoholic liver disease,non-alcoholic fatty liver disease,chemical liver injury,drug-induced liver injury and liver fibrosis,which could serve to guide drug discovery for liver diseases and resource utilization of D.huoshanense.

关 键 词：霍山石斛 活性成分 保肝 肝脏疾病 抗氧化 抑制炎症 

分 类 号：R284.1[医药卫生—中药学]