高内脏脂肪指数与高尿酸血症的相关性分析  

Correlation analysis of high visceral adiposity index and hyperuricemia

作　　者：张少杰 秦献辉[1,2,3] 李幼宝[3] 臧桐华[1,2] 徐希平 王滨燕[1,2,4] ZHANG Shao-jie;QIN Xian-hui;LI You-bao;ZANG Tong-hua;XU Xi-ping;WANG Bin-yan(Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,Hefei 230032,China;Institute of Biomedicine,Anhui Medical University,Hefei 230032,China;Nanfang Hospital,Southern Medical University,National Clinical Research Center for Kidney Disease,Guangzhou 510515,China;Shenzhen Evergreen Medical Institute,Shenzhen 518057,China)

机构地区：[1]安徽医科大学流行病与卫生统计学教研室,合肥230032 [2]安徽医科大学生物医学研究所,合肥230032 [3]南方医科大学南方医院,国家临床研究中心,广州510515 [4]深圳市长卿医学研究院,深圳518057

出　　处：《中华疾病控制杂志》2022年第12期1414-1419,共6页Chinese Journal of Disease Control & Prevention

基　　金：国家重点研究项目(2016YFE0205400,2018ZX09739010,2018ZX09301034003)。

摘　　要：目的 探讨连云港市高血压人群内脏脂肪指数(visceral adiposity index, VAI)水平与新发高尿酸血症(hyperuricemia, HUA)的相关性,为HUA的早期预防以及疾病控制提供参考和依据。方法 本研究来自中国脑卒中一级预防试验的尿酸子研究,共10 513名尿酸正常[尿酸<357μmol/L (6 mg/dL)]的高血压患者纳入分析。本研究主要终点为新发HUA,定义为末次随访男性血尿酸浓度≥417μmol/L(7 mg/dL)或女性血尿酸浓度≥357μmol/L(6 mg/dL)。结果 本研究共纳入了10 513例尿酸正常的高血压受试者。平均随访4.4年之后,共有1 642(15.6%)例受试者发生了HUA。分析结果显示,与VAI<2.98(第一至三分位)的受试者相比,VAI≥2.98(第四分位)的受试者新发HUA的发生风险升高(13.8%vs. 21.1%;OR:1.17;95%CI:1.01~1.36;P<0.001)。此外,分层分析显示这种风险关系独立于组成VAI的四个指标(交互作用均有P>0.05)。结论 在连云港市的高血压人群中,VAI越大的人群患上HUA的风险越高。Objective The relation between visceral adiposity index(VAI) and new-onset hyperuricemia remains largely understudied. This study seeks to further investigate the association between VAI and the risk of hyperuricemia by examining possible effect modifies in hypertensive patients. Methods A total of 10 513 hypertensive patients with normal uric acid(UA) concentrations [<357 μmol/L(6 mg/dL)] who participated the UA Sub-study of the China Stroke Primary Prevention Trial(CSPPT) were enrolled. Our primary outcome was new-onset hyperuricemia, which was defined as a UA concentration ≥417 μmol/L(7 mg/dL) in men or ≥357 μmol/L(6 mg/dL) in women at the exit visit. Results Over a median follow-up of 4.4 years, 1 642(15.6%) participants developed new-onset hyperuricemia. When VAI was assessed as quartiles, a significantly higher risk of new-onset hyperuricemia was found in participants in quartile 4(≥2.98;OR:1.17;95% CI: 1.01-1.36) compared with those in quartile 1-3(<2.98). Furthermore, the positive relation was independent of abnormal VAI components or numbers of abnormal VAI components(all Pinteractions>0.05). Conclusions There is a positive relationship between baseline VAI and the risk of new-onset hyperuricemia in a sample of Chinese hypertensive individuals.

关 键 词：内脏脂肪指数 尿酸 新发高尿酸血症 高血压 

分 类 号：R512.8[医药卫生—内科学]