老年人群肠道菌群α多样性影响因素研究  

Study on factors influencing gut microbiota α diversity in the older people

作　　者：殷召雪[1] 白雪梅[2] 张晶睿 姜远静 闫斐 木克热木·于努斯 高欣[1] 吴静[1] YIN Zhao-xue;BAI Xue-mei;ZHANG Jing-rui;JIANG Yuan-jing;YAN Fei;MUKARAM·Yunus;GAO Xin;WU Jing(Division of non-communicable diseases and elderly health management,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Capital Medical University,Beijing 100069,China;Yuanbao Center for Disease Control and Prevention,Dandong 118001,China;Korla Center for Disease Control and Prevention,Korla 841004,China)

机构地区：[1]中国疾病预防控制中心慢病和老龄健康管理处,北京102206 [2]首都医科大学,北京100069 [3]丹东市元宝区疾病预防控制中心,丹东118001 [4]新疆库尔勒市疾病预防控制中心,库尔勒841000

出　　处：《中华疾病控制杂志》2022年第12期1433-1437,共5页Chinese Journal of Disease Control & Prevention

基　　金：公共卫生应急反应机制的运行-慢病防治项目(131031001000210001);科技部重点研发计划项目(2020YFC2003000)。

摘　　要：目的 研究老年人肠道菌群α多样性的影响因素。方法 对社区老年人肠道菌群16Sr-DNA测序并分析菌群α多样性。按照四分位数将α多样性分为“高”和“低”两组,利用logistic回归分析模型分析肠道菌群α多样性的影响因素。结果 多因素logistic回归分析模型分析结果显示,与最低三分位数组相比,精制谷物和水果摄入量最高三分位数组肠道菌群“高”Shannon指数OR(95%CI)值分别为0.57(0.36~0.89)和1.86(1.15~3.02);较高频次酸菜/泡菜摄入者肠道菌群“高”Shannon指数OR(95%CI)值为0.47(0.27~0.81)。与Shannon指数类似,精制谷物、酸菜/泡菜和水果也是Simpson指数的影响因素,此外,性别也是Simpson指数的影响因素(P=0.028)。结论 增加水果摄入有助于增加老年人肠道菌群α多样性,而精制谷物、酸菜/泡菜的摄入则可能不利于α多样性的增加。Objective To explore factors influencing α diversity of gut micro-biota in the older people. Methods Stool samples were collected to extract gut microbiota DNA, 16 Sr-DNA sequencing was conducted, and gut microbiota α diversity was analyzed. α diversity was categorized as ‘High’ or ‘Low’ according to the quantile of every indicator. Logistic regression models were run to analyze the potential factors that influencing gut microbiota diversity. Results Multivariate logistic regressions showed, compared with the lowest tertile group, OR(95% CI) of high Shannon index in the higher tertile group of refined grain and fruit intake was 0.57(0.37-0.88) and 2.03(1.27-3.24), respectively. Compared with the low group, the possibility of high Shannon index in the high group of pickle intake frequency declined, with OR of 0.45(0.26-0.78). Similarly with Shannon index, refined grain, pickles intake frequency, and fruit intake were all factors influencing the Simpson’s index, as well as sex(P=0.028). Conclusions Increasing fruit intake may be beneficial for α diversity of gut microbiota, while intake of refined grain and pickles may be harmful in the older people.

关 键 词：肠道菌群α多样性 影响因素 老年人 

分 类 号：R117[医药卫生—公共卫生与预防医学]