葛根芩连汤治疗湿热型冠心病心绞痛的疗效及对肠道菌群的影响  

Curative effect of Gegen Qinlian Decoction on damp-heat type coronary heart disease with angina pectoris and its influence on intestinal flora

作　　者：张小兵[1] 曾玲玲 刘云[1] 夏思良[1] ZHANG Xiao-bing;ZENG Ling-ling;LIU Yun;XIA Si-liang(Department of Cardiovascular Medicine,Nanjing Jiangbei Hospital Affiliated to Nantong University,Nanjing,Jiangsu 210048,China;不详)

机构地区：[1]南通大学附属南京江北医院心血管内科,江苏南京210048 [2]南通大学附属南京江北医院中医科,江苏南京210048

出　　处：《中国临床研究》2022年第12期1737-1740,共4页Chinese Journal of Clinical Research

摘　　要：目的探讨葛根芩连汤对湿热型冠状动脉粥样硬化性心脏病(冠心病)心绞痛的治疗效果,及其对肠道菌群的影响。方法纳入自2020年1月至2022年5月在南京江北医院住院治疗的湿热型稳定性冠心病心绞痛患者118例。采用随机数字表法将患者分为对照组和研究组,每组各59例。对照组患者采用阿托伐他汀+安慰剂治疗,研究组患者采用阿托伐他汀+葛根芩连汤治疗,两组均治疗12周。对比两组疗效及治疗前后血脂水平和肠道菌群分布情况。结果研究组的治疗总有效率高于对照组(84.75%vs 64.41%,P=0.011)。两组患者在TC、TG和LDL-C水平上,治疗后均明显下降,HDL-C水平均升高,且治疗后研究组TC、TG和LDL-C的水平显著低于对照组,HDL-C的水平明显高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后乳酸杆菌和双歧杆菌的水平均上升,而大肠杆菌、肠球菌的水平明显下降,且相比于对照组,研究组的双歧杆菌的水平较高,而大肠杆菌和肠球菌的水平较低,差异有统计学意义(P<0.05)。结论葛根芩连汤治疗湿热型冠心病心绞痛可以改善患者症状,调节患者血脂水平和肠道菌群。Objective To explore the therapeutic effect of Gegen Qinlian Decoction on damp-heat type coronary atherosclerotic heart disease(CHD)with angina pectoris and its influence on intestinal flora.Methods From January 2020 to May 2022,118 patients with damp-heat type stable CHD with angina pectoris hospitalized in Nanjing Jiangbei Hospital were included and divided into control group and study group randomly(n=59,each).The patients in the control group were treated with atorvastatin+placebo,and the patients in the study group were treated with atorvastatin+Gegen Qinlian Decoction.Both groups were treated for 12 weeks.The curative effect,blood lipid level and intestinal flora distribution before and after treatment were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group(84.75%vs 64.41%,P=0.011).The levels of TC,TG and LDL-C in the two groups decreased significantly after treatment,while the levels of HDL-C increased.After treatment,the levels of TC,TG and LDL-C in the study group were significantly lower than those in the control group,and the level of HDL-C was significantly higher than that in the control group(P<0.05).After treatment,the levels of Lactobacillus and Bifidobacteria increased in both groups,while the levels of Escherichia coli and Enterococcus decreased significantly,and compared with the control group,the levels of Bifidobacteria in the study group were higher,while the levels of Escherichia coli and Enterococcus were lower(P<0.05).Conclusion Gegen Qinlian Decoction can improve the symptoms of patients with damp-heat rype CHD with angina pectoris,regulate the blood lipid levels and intestinal flora.

关 键 词：冠状动脉粥样硬化性心脏病 湿热型 肠道菌群 葛根芩连汤 血脂 阿托伐他汀 

分 类 号：R541.4[医药卫生—心血管疾病] R259[医药卫生—内科学]