悬雍垂腭咽成形术与持续气道内正压通气对阻塞性睡眠呼吸暂停低通气综合征患者的疗效分析  

Efficacy analysis of uvulopalatopharyngoplasty and continuous positive airway pressure on patients with obstructive sleep apnea hypopnea syndrome

作　　者：孙国通 刘宇 杨珂 SUN Guo-tong;LIU Yu;YANG Ke(Shouguang Hospital of Traditional Chinese Medicine,Shouguang 262700,China)

机构地区：[1]寿光市中医医院,262700 [2]内蒙古民族大学,021000 [3]山东大学齐鲁医院(青岛),266035

出　　处：《中国现代药物应用》2023年第1期35-38,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 探讨悬雍垂腭咽成形术(UPPP)与持续气道内正压通气(CPAP)对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的疗效。方法 40例OSAHS患者,根据治疗方法不同分为UPPP组与CPAP组,各20例。UPPP组给予UPPP治疗, CPAP组给予CPAP治疗。比较两组治疗前后血压及凝血指标[凝血酶原时间(PT)、部分凝血活酶时间(APTT)]。结果 UPPP组收缩压、舒张压、PT、APTT:治疗前分别为(158.9±1.2)mm Hg(1 mm Hg=0.133 kPa)、(107.6±5.0)mm Hg、(10.2±0.4)s、(32.1±2.7)s,治疗后15 d分别为(154.5±2.1)mm Hg、(103.7±4.7)mm Hg、(10.5±0.4)s、(33.8±2.4)s,治疗后30 d分别为(150.6±6.1)mm Hg、(99.0±9.5)mm Hg、(10.9±0.5)s、(34.9±2.6)s,治疗后90 d分别为(144.3±5.9)mm Hg、(85.4±9.3)mm Hg、(11.8±0.4)s、(36.1±2.5)s;CPAP组收缩压、舒张压、PT、APTT:治疗前分别为(159.4±1.2)mm Hg、(105.5±5.9)mm Hg、(10.1±0.4)s、(32.2±2.5)s,治疗后15 d分别为(155.0±4.9)mm Hg、(102.3±3.1)mm Hg、(10.5±0.5)s、(33.9±2.5)s,治疗后30 d分别为(152.0±2.1)mm Hg、(99.7±7.8)mm Hg、(10.8±0.4)s、(34.8±2.6)s,治疗后90 d分别为(145.7±3.1)mm Hg、(86.1±7.7)mm Hg、(11.7±0.6)s、(35.9±2.7)s。治疗后15、30、90 d,两组收缩压、舒张压低于治疗前, PT、APTT长于治疗前,差异有统计学意义(P<0.05);治疗后15、30、90 d,两组收缩压、舒张压、PT、APTT组间比较,差异无统计学意义(P>0.05)。结论 OSAHS患者存在明显的高血压及高凝状态, UPPP及CPAP治疗具有良好的效果,且两者效果接近。Objective To discuss the efficacy of uvulopalatopharyngoplasty(UPPP) and continuous positive airway pressure(CPAP) on patients with obstructive sleep apnea hypopnea syndrome(OSAHS). Methods A total of 40 patients with OSAHS were divided into UPPP group and CPAP group according to different treatment methods, with 20 patients in each group. UPPP group received UPPP treatment, CPAP group received CPAP treatment. Both groups were compared in terms of blood pressure, coagulation index [prothrombin time(PT) and activated partial thromboplastin time(APTT)] before and after treatment. Results In UPPP group, the systolic blood pressure, diastolic blood pressure, PT, APTT were(158.9±1.2) mm Hg(1 mm Hg=0.133 kPa),(107.6±5.0) mm Hg,(10.2±0.4) s,(32.1±2.7) s before treatment,(154.5±2.1) mm Hg,(103.7±4.7) mm Hg,(10.5±0.4) s,(33.8±2.4) s at 15 d after treatment,(150.6±6.1) mm Hg,(99.0±9.5) mm Hg,(10.9±0.5) s,(34.9±2.6) s at 30 d after treatment, and(144.3±5.9) mm Hg,(85.4±9.3) mm Hg,(11.8±0.4) s,(36.1±2.5) s at 90 d after treatment. In CPAP group, the systolic blood pressure, diastolic blood pressure, PT, APTT were(159.4±1.2) mm Hg,(105.5±5.9) mm Hg,(10.1±0.4) s, and(32.2±2.5) s before treatment,(155.0±4.9) mm Hg,(102.3±3.1) mm Hg,(10.5±0.5) s,(33.9±2.5) s at 15 d after treatment,(152.0±2.1) mm Hg,(99.7±7.8) mm Hg,(10.8±0.4) s,(34.8±2.6) s at 30 d after treatment, and(145.7±3.1) mm Hg,(86.1±7.7) mm Hg,(11.7±0.6) s,and(35.9±2.7) s at 90 d after treatment. At 15, 30 and 90 d after treatment, the systolic blood pressure and diastolic blood pressure in the two groups were lower than those before treatment in this group, and PT and APTT were longer than those before treatment in this group, and the differences were statistically significant(P<0.05). At 15, 30 and 90 d after treatment, there was no statistically significant difference between the two groups in terms of systolic blood pressure, diastolic blood pressure, PT, and APTT(P>0.05).Conclusion Patients with OSAHS have significant hypertension a

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 悬雍垂腭咽成形术 持续气道内正压通气 血压 凝血系统 

分 类 号：R766[医药卫生—耳鼻咽喉科]