血浆纤维蛋白原、D-二聚体在结核性渗出性胸膜炎鉴别诊断中的临床价值分析  

Analysis of the clinical value of plasma fibrinogen, D-dimer in the differential diagnosis of tuberculous exudative pleurisy

作　　者：王琤[1] WANG Zheng(Laboratory Department,Shenyang Tenth People's Hospital,Shenyang 110000,China)

机构地区：[1]沈阳市第十人民医院检验科,110000

出　　处：《中国现代药物应用》2023年第1期67-69,共3页Chinese Journal of Modern Drug Application

摘　　要：目的通过检测结核性渗出性胸膜炎患者的血浆纤维蛋白原(FIB)、D-二聚体(D-D)水平及阳性率,研究FIB、D-D对结核性渗出性胸膜炎鉴别诊断的临床价值。方法42例经胸腔镜确诊的胸腔积液患者,根据病理诊断结果不同分为结核性渗出性胸膜炎组(29例)和恶性胸腔积液组(13例)。采集两组患者的空腹静脉血,检测其血浆FIB、D-D水平。比较两组患者的血浆FIB、D-D水平及阳性率。结果结核性渗出性胸膜炎组患者的血浆FIB、D-D水平分别为(7.02±1.29)g/L、(3.87±1.56)mg/L,高于恶性胸腔积液组的(5.88±0.85)g/L、(2.28±1.04)mg/L,差异均有统计学意义(P<0.05)。结核性渗出性胸膜炎组患者血浆FIB、D-D阳性率分别为79.31%、93.10%,高于恶性胸腔积液组的46.15%、46.15%,差异具有统计学意义(P<0.05)。结论结核性渗出性胸膜炎患者的血浆FIB、D-D水平及阳性率均明显高于恶性胸腔积液,临床上可以通过检测血浆FIB、D-D水平鉴别结核性渗出性胸膜炎与恶性胸腔积液,能够为临床诊断和治疗提供有效指导,临床价值较高。Objective To study the clinical value of plasma fibrinogen(FIB), D-dimer(D-D) in the differential diagnosis of tuberculous exudative pleurisy by investigating the levels of FIB and D-D in patients with tuberculous exudative pleurisy. Methods 42 patients with pleural effusion diagnosed by thoracoscopy were divided into the tuberculous exudative pleurisy group(29 patients) and the malignant pleural effusion group(13 patients) according to the different pathological diagnoses. Fasting venous blood was collected from patients in both groups, and their plasma FIB and D-D levels were measured. The plasma FIB and D-D levels and the positive rate of the two groups were compared. Results The plasma FIB and D-D levels in the tuberculous exudative pleurisy group were(7.02±1.29) g/L and(3.87±1.56) mg/L, which were higher than(5.88±0.85) g/L and(2.28±1.04) mg/L in the malignant pleural effusion group, and the differences were statistically significant(P<0.05). The positive rates of plasma FIB and D-D in the tuberculous exudative pleurisy group were 79.31% and 93.10%, which were higher than 46.15% and 46.15% in the malignant pleural effusion group, and the differences were statistically significant(P<0.05). Conclusion The levels of plasma FIB and D-D in patients with tuberculous exudative pleurisy were higher than those in patients with malignant pleural effusion. Clinically, the plasma FIB and D-D levels can be used to identify tuberculous exudative pleurisy from malignant pleural effusion,which can provide effective guidance for clinical diagnosis and treatment, and is of high clinical value.

关 键 词：结核性渗出性胸膜炎 恶性胸腔积液 纤维蛋白原 D-二聚体 鉴别诊断 

分 类 号：R521.7[医药卫生—内科学]