缺氧诱导因子-1α在渗出性老年性黄斑变性中的研究进展  

Research Progress of Hypoxia-Inducible Factor-1α on Exudative Senile Macular Degeneration

作　　者：梁慧颖 曹明芳[2] LIANG Huiying;CAO Mingfang(Fujian University of Traditional Chinese Medicine,Fujian Fuzhou 350122,China;Peoples Hospital Affiliated of Fujian University of Traditional Chinese Medicine,Fujian Fuzhou 350004,China)

机构地区：[1]福建中医药大学,福建福州350122 [2]福建中医药大学附属人民医院,福建福州350004

出　　处：《中医药临床杂志》2023年第1期189-195,共7页Clinical Journal of Traditional Chinese Medicine

基　　金：福建省自然科学基金面上项目(项目编号:2020J011046);2018年度中药制剂专项研究(项目编号:ZYZJ2019003)。

摘　　要：缺氧所导致的缺氧诱导因子-1α的稳定表达是渗出性老年性黄斑变性发病的重要因素,而渗出性老年性黄斑变性的突出表现脉络膜新生血管亦是缺氧所促发。缺氧所诱发的上游信号通路可以通过激活缺氧诱导因子-1α,进而使缺氧诱导因子-1α可以调控下游的一系列参与新生血管生成的相关因子;缺氧诱导因子-1α及下游因子的共同调控作用最终导致脉络膜新生血管生成。该综述通过总结前人对缺氧诱导因子-1α在渗出性老年性黄斑变性中的研究成果,以探求二者之间的相关性及为临床治疗提供新思路。The stable expression of hypoxia-inducible factor-1α caused by hypoxia is an important factor in the pathogenesis of exudative age-related macular degeneration, and the prominent manifestation of exudative age-related macular degeneration is also triggered by hypoxia. The upstream signaling pathway induced by hypoxia can activate hypoxia-inducible factor-1α, so that hypoxia-inducible factor-1α can regulate a series of downstream related factors involved in neovascularization;hypoxia-inducible factor-1α and downstream factors Co-regulation ultimately leads to choroidal neovascularization. This review summarizes previous research results on hypoxia-inducible factor-1a in exudative age-related macular degeneration, in order to explore the correlation between the two and provide new ideas for clinical treatment.

关 键 词：渗出性老年性黄斑变性 缺氧诱导因子-1Α 缺氧 脉络膜新生血管 信号通路 促血管生成因子 治疗 

分 类 号：R276.7[医药卫生—中医五官科学]