替米考星可溶性粉在乌鸡体内的药动学研究  

Pharmacokinetic of Tilmicosin Soluble Powder in Black-Bone Chickens

作　　者：秦晓冰[1] QIN Xiaobing(Shandong Key Laborary of Preventive Veterinary Medicine,Qingdao agricultural University,Qingdao 266109,China)

机构地区：[1]青岛农业大学/山东省预防兽医学重点实验室,山东青岛266109

出　　处：《家禽科学》2022年第12期10-14,共5页Poultry Science

基　　金：山东省兽药诊断试剂工程技术研究中心项目;山东省高等学校优势学科人才团队培育计划。

摘　　要：为研究替米考星可溶性粉在乌鸡体内的药动学特征,选24只(公母各半)体重相近的60日龄健康乌鸡,随机均分为2组,按照12 mg/kg体重剂量口服替米考星可溶性粉溶液,在给药后0.25、0.5、1、2、4、6、8、12、16、24、48、72 h分别采血1次,每次2 mL,用高效液相测谱法测定药动力学参数并分析,预试期14d,正试期3d。结果表明:消除半衰期(T1/2β)为(33.786±14.720)h,达峰时间(T_(max))为(1.125±0.311)h,峰浓度(C_(max))为(0.377±0.234)μg/mL,药时曲线下面积(AUC)为(2.322±0.713)μg/mL·h,平均滞留时间(MRT)为(9.346±1.155)h。研究表明,替米考星在乌鸡体内吸收快、分布广,消除缓慢,有很好的利用前景。In order to study the pharmacokinetic characteristics of tilmicosin soluble powder in black-bone chickens,2460-day-old healthy black-bone chickens(half male and half female)with similar body weight were selected and randomly divided into two groups.After the chickens were fed tilmicosin soluble powder solution as 12mg/kg body weight,blood was collected once 2 mL each time at 0.25,0.5,1,2,4,6,8,12,16,24,48,and 72 h,then pharmacokinetic parameters were determined and analyzed by high-performance liquid spectrometry.The pretrial period was 14 days and the positive trial period was 3 days.The results showed that the elimination half-life(T1/2β)was(33.786±14.720)h,the peak time(T_(max))was(1.125±0.311)h,and the peak concentration(C_(max))was(0.377±0.234)μg/mL.The lower area(AUC)was(2.322±0.713)μg/mL·h,and the mean retention time(MRT)was(9.346±1.155)h.It has demonstrated that tilmicosin can be rapidly absorbed,widely distributed,and slowly eliminated in black-bone chickens,thus has a desired prospect of utilization.

关 键 词：替米考星 可溶性粉 乌鸡 药动力学 

分 类 号：S859[农业科学—临床兽医学]