反式和顺式二苯乙烯苷在大鼠体内的药代动力学比较研究  

Comparison of pharmacokinetic parameters of trans- and cis-2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside on rats

作　　者：柴士伟[1,2] 高建 厍立鹤 于俏 庞旭 韩立峰 CHAI Shiwei;GAO Jian;SHE Lihe;YU Qiao;PANG Xu;HAN Lifeng(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300193,China;Key Laboratory of Traditional ChineseMedicinal Chemistry and Analytical Chemistry of Tianjin,Tianjin 301617,China)

机构地区：[1]天津中医药大学第一附属医院,天津300193 [2]国家中医针灸临床医学研究中心,天津300193 [3]天津市中药化学与分析重点实验室,天津301617

出　　处：《天津中医药》2023年第1期104-109,共6页Tianjin Journal of Traditional Chinese Medicine

基　　金：天津市教委科研计划项目一般项目(2017KJ128)。

摘　　要：[目的]比较何首乌中反式二苯乙烯苷和顺式二苯乙烯苷在大鼠体内的药代动力学差异。[方法]分别单次灌胃给药(60 mg/kg)反式二苯乙烯苷和顺式二苯乙烯苷后,测定大鼠给药后不同时间点的血浆中药物浓度,通过计算药代动力学参数,比较两者的体内药动学行为差异。[结果]单次给药反式二苯乙烯苷和顺式二苯乙烯苷后,大鼠血浆中顺式二苯乙烯苷的半衰期(T1/2)显著高于反式二苯乙烯苷(P<0.05),而反式二苯乙烯苷在大鼠体内的达峰浓度(Cmax)和清除率(CLz/F)则显著高于顺式二苯乙烯苷(P<0.05)。[结论]单次给予相同浓度的反式二苯乙烯苷和顺式二苯乙烯苷后,两者在大鼠体内的药代动力学行为存在明显差异。[Objective]Comparison of the pharmacokinetic differences of trans-2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside(trans-TSG)and cis-2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside(cis-TSG)in Polygonum multiflorum Thunb.in rats.[Methods]After a single intragastric administration of 60 mg/kg of trans-TSG and cis-TSG,the drug concentrations in the plasma of rats were determined at different time points and the in vivo pharmacokinetic parameters were calculated.[Results]Significant differences were found in pharmacokinetic parameters.T1/2 of cis-TSG was significantly higher than that of trans-TSG(P<0.05).However,CLz/F,and Cmax of trans-TSG in the plasma were significantly higher than cis-TSG(P<0.05).[Conclusion]The pharmacokinetic behavior of trans-TSG and cis-TSG in rats was significantly different following a single intragastric administration of the same concentrations of them.

关 键 词：何首乌 反式二苯乙烯苷 顺式二苯乙烯苷 药代动力学 单次给药 

分 类 号：R284.1[医药卫生—中药学]