洛匹那韦治疗对梅毒并HIV感染者免疫功能、CK⁃MB及LDH的影响  

Effects of lopinavir treatment on immune function,CK⁃MB and LDH in patients with syphilis and HIV infection

作　　者：李双会[1] 霍枚玫 王娅茹[1] 王丽娜[2] LI Shuanghui;HUO Meimei;WANG Yaru;WANG Lina(Hanzhong Vocational and Technical College,Hanzhong,Shaanxi,China,723002;Department of Dermatology,Hanzhong People's Hospital,Hanzhong,Shaanxi,China,723000)

机构地区：[1]汉中职业技术学院,陕西汉中723002 [2]汉中市人民医院皮肤科,陕西汉中723000

出　　处：《分子诊断与治疗杂志》2022年第12期2094-2097,共4页Journal of Molecular Diagnostics and Therapy

基　　金：陕西省科学技术项目(2018⁃01⁃0126)。

摘　　要：目的研究洛匹那韦治疗对梅毒并人类免疫缺陷病毒(HIV)感染患者免疫功能、肌酸激酶同工酶(CK⁃MB)及乳酸脱氢酶(LDH)的影响。方法选取2018年9月至2021年9月于汉中市人民医院就诊的103例梅毒合并HIV感染患者,根据治疗方案不同分为对照组(n=50,苄星青霉素治疗)和研究组(n=53,洛匹那韦联合苄星青霉素治疗)。对比两组临床疗效、免疫功能(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、CK⁃MB及LDH水平及不良反应。结果研究组临床疗效(92.45%)高于对照组(78.00%),差异有统计学意义(P<0.05)。治疗3周后研究组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于对照组,差异均有统计学意义(P<0.05)。治疗后3周后两组CK⁃MB、LDH水平均下降,且研究组低于对照组,差异均有统计学意义(P<0.05)。研究组不良反应率(22.64%)与对照组不良反应率(14.00%)比较,差异无统计学意义(P>0.05)。结论对梅毒合并HIV感染患者采用洛匹那韦联合苄星青霉素治疗可有效提高临床疗效,能使患者免疫功能及CK⁃MB、LDH水平得到显著改善,联合用药具有一定安全性。Objective To study the effects of lopinavir treatment on immune function,creatine kinase⁃MB(CK⁃MB)and lactate dehydrogenase(LDH)in patients with syphilis and human immunodeficiency virus(HIV)infection.Methods 103 patients with syphilis complicated with HIV infection who were treated in Hanzhong People's Hospital from September 2018 to September 2021 were selected,according to different treatment regimens,and they were divided into the control group(n=50,benzacin penicillin treatment)and the study group(n=53,lopinavir combined with benzacin penicillin treatment).Clinical efficacy,immune function(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),CK⁃MB and LDH levels and adverse reactions were compared between the two groups.Results The clinical efficacy of the study group(92.45%)was higher than that of the control group(78.00%),and the difference was statistically significant(P<0.05).After 3 weeks of treatment,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).After 3 weeks of treatment,the levels of CK⁃MB and LDH in the two groups all decreased,and those in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the adverse reaction rate between the study group(22.64%)and the control group(14.00%)(P>0.05).Conclusion The use of lopinavir combined with benzathine penicillin in the treatment of syphilis patients with HIV infection can effectively improve the clinical efficacy,and can significantly improve the immune function and the levels of CK⁃MB and LDH in patients,and the combination therapy has certain safety.

关 键 词：梅毒合并HIV 洛匹那韦 苄星青霉素 免疫功能 CK⁃MB LDH 

分 类 号：R759.1[医药卫生—皮肤病学与性病学] R512.91[医药卫生—临床医学]