血清ADA、ANA、抗CCP抗体与类风湿关节炎合并骨关节炎预后的相关性  

Correlation between serum ADA,ANA and anti⁃CCP antibodies and prognosis of rheumatoid arthritis complicated with osteoarthritis

作　　者：魏竹节 王涛[1] 李志军[1] WEI Zhujie;WANG Tao;LI Zhijun(Department of Rheumatology and Immunology,The First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui,China,233400)

机构地区：[1]蚌埠医学院第一附属医院风湿免疫科,安徽蚌埠233400

出　　处：《分子诊断与治疗杂志》2022年第12期2115-2118,2124,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省卫生健康软科学研究项目(2020WR03013)。

摘　　要：目的探究血清腺苷脱氨酶(ADA)、抗核抗体(ANA)、抗环瓜氨酸肽(CCP)抗体与类风湿关节炎(RA)合并骨关节炎(OA)预后的相关性。方法收集2020年1月至2021年6月蚌埠医学院第一附属医院风湿免疫科收治的RA合并OA88例患者,根据预后结果分为预后良好组(RF<16.294 IU/mL,n=78)L和预后不良组(RF≥16.294 IU/mL,n=10),比较两组间的临床资料以及血清ADA表达水平以及ANA和抗CCP抗体的阳性率;采用spearman分析法分析各组患者血清ADA、ANA、抗CCP抗体与类风湿关节炎合并骨关节炎预后不良的相关性;采用多因素Logistic回归分析RA合并OA预后不良的影响因素,并绘制受试者工作(ROC)曲线判断血清ADA、ANA、抗CCP抗体对类风湿关节炎合并骨关节炎预后不良的预测价值。结果预后良好组与预后不良组的血清ADA、ANA、抗CCP抗体水平比较差异有统计学意义(t=2.374,x^(2)=4.412,5.533,P<0.05);经Spearman相关分析,患者的血清ADA、ANA、抗CCP抗体水平与类风湿关节炎合并骨关节炎预后不良呈正相关(P<0.05);Logistic回归分析结果显示,血清ADA、ANA、抗CCP抗体为RA合并OA患者预后不良的独立危险因素(P<0.05)。ROC曲线分析结果显示,血清ADA、ANA、抗CCP抗体以及联合检测预测类风湿关节炎合并骨关节炎预后不良的曲线下面积分别为0.791、0.826、0.841、0.911。结论血清ADA、ANA、抗CCP抗体三者联合检测预测类风湿关节炎合并骨关节炎预后不良的预测价值较高,可以为类风湿关节炎合并骨关节炎患者预测预后结局提供理论依据。Objective To explore the correlation between serum adenosine deaminase(ADA),antinuclear antibody(ANA),anticyclic citrullinated peptide(CCP)antibody and the prognosis of rheumatoid arthritis(RA)complicated with osteoarthritis(OA).Methods A total of 88 patients with RA complicated by OA who were admitted to the Department of Rheumatology and Immunology,The First Affiliated Hospital of Bengbu Medical College from January 2020 to June 2021 were collected.According to the prognosis,they were divided into a good prognosis group(n=78)and a poor prognosis group(n=10),the clinical data,se⁃rum ADA expression levels,and the positive rates of ANA and anti⁃CCP antibodies were compared between the two groups.Spearman analysis was used to analyze the correlation between serum ADA,ANA,anti⁃CCP antibody and poor prognosis of rheumatoid arthritis combined with osteoarthritis in patients in each group;mul⁃tivariate Logistic regression was used to analyze the influencing factors of poor prognosis of RA combined with OA,and the subjects were plotted The receiver operating characteristic(ROC)curve was used to judge the predictive value of serum ADA,ANA,and anti⁃CCP antibody on the poor prognosis of rheumatoid arthritis combined with osteoarthritis.Results There were significant differences in serum ADA,ANA and anti⁃CCP antibody levels between the good prognosis group and the poor prognosis group(t=2.374,x^(2)=4.412,5.533,P<0.05).The levels of ANA and anti⁃CCP antibodies were positively correlated with the poor prognosis of rheumatoid arthritis combined with osteoarthritis(P<0.05).Logistic regression analysis showed that serum ADA,ANA and anti⁃CCP antibodies were independent risk factors for poor prognosis in patients with RA combined with OA.(P<0.05).The results of ROC curve analysis showed that the areas under the curve of se⁃rum ADA,ANA,anti⁃CCP antibodies and combined detection for predicting poor prognosis of rheumatoid ar⁃thritis combined with OA were 0.791,0.826,0.841,and 0.911,respectively.Conclusion The c

关 键 词：血清腺苷脱氨酶 抗核抗体 抗环瓜氨酸肽 类风湿关节炎 骨关节炎 

分 类 号：R593.22[医药卫生—内科学] R684.3[医药卫生—临床医学]