基于聚中性红/多壁碳纳米管复合材料的比率型电化学传感器检测雌三醇  

Poly(neutral red)/Multi-walled Carbon Nanotube Composite Modified Electrochemical Sensor for Ratiometric Detection of Estriol

作　　者：孙志远 樊文芳 王勇[1] 庄欠粉[1] SUN Zhi-Yuan;FAN Wen-Fang;WANG Yong;ZHUANG Qian-Fen(School of Chemistry and Chemical Engineering,Nanchang University,Nanchang 330031,China)

机构地区：[1]南昌大学化学化工学院,南昌330031

出　　处：《分析化学》2023年第1期42-52,共11页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(Nos.31960495,32160600,21864017)资助。

摘　　要：基于聚中性红/多壁碳纳米管复合材料构建了检测雌三醇的比率型电化学传感器,利用聚中性红作为内参比电活性探针,雌三醇与聚中性红的氧化峰电流比值作为比率电化学信号,实现了雌三醇的定量检测。聚中性红/多壁碳纳米管复合材料具有良好的电导率和电催化性能,可提高检测灵敏度。实验结果表明,雌三醇在聚中性红/多壁碳纳米管复合材料修饰的玻碳电极上发生双电子和双质子的电化学氧化过程。传感器检测雌三醇的线性范围为0.1~2.0μmol/L,检出限为0.08μmol/L(S/N=3)。此传感器具有灵敏度高、抗干扰能力强及稳定性好等优点,可用于雌三醇药膏、人尿液和湖水样中雌三醇的分析。A poly(neutral red)/multi-walled carbon nanotube nanocomposite modified electrochemical sensor was established for ratiometric sensing of estriol.The poly(neutral red)was used as the internal reference electroactive probe,and the oxidation peak current ratio of estriol to poly(neutral red)was used for accurate quantitative detection of estriol.The poly(neutral red)/multi-walled carbon nanotube nanocomposite was demonstrated good electroconductivity and high electrocatalytic performance which could improve the detection sensitivity.The response of the ratiometric sensor was linearly proportion to the estriol concentration in the 0.1-2.0μmol/L range,with a limit of detection(S/N=3)of 0.08μmol/L.The electrochemical oxidation reaction of estriol on the poly(neutral red)/multiwalled carbon nanotube nanocomposite/glassy carbon electrode was demonstrated to undergo a two-electron/two-proton process.Moreover,the sensor had high sensitivity,strong anti-interference ability and good stability,and was successfully applied to testriol analysis in pharmaceutical cream,urine and lake water samples.

关 键 词：雌三醇 聚中性红 比率型传感器 电化学 

分 类 号：O657.1[理学—分析化学] TB332[理学—化学] TP212.2[一般工业技术—材料科学与工程]