排石颗粒联合盐酸坦洛新用于上尿路结石软性输尿管镜钬激光碎石术临床评价  

Clinical Evaluation of Paishi Granules Combined with Tamsulosin Hydrochloride in the Treatment of Patients with Upper Urinary Calculi Undergoing Flexible Ureteroscope Lithotripsy

作　　者：刘庆辉 张志超 姚丽 王丽叶 白栩搏 LIU Qinghui;ZHANG Zhichao;YAO Li;WANG Liye;BAI Xubo(Department of Urology,Xingtai General Hospital,North China Health Group,Xingtai,Hebei,China 054000)

机构地区：[1]华北医疗健康集团邢台总医院泌尿外科,河北邢台054000

出　　处：《中国药业》2023年第2期97-100,共4页China Pharmaceuticals

基　　金：河北省邢台市科技计划项目[2019ZC327]。

摘　　要：目的探讨排石颗粒联合盐酸坦洛新对行软性输尿管镜钬激光碎石术(FURSL)治疗的上尿路结石患者术后残余结石的清除效果。方法选取医院2020年8月至2021年8月收治的上尿路结石患者100例,按随机数字表法分为对照组和观察组,各50例。两组患者均择期行FURSL治疗,术后口服盐酸坦洛新缓释片,观察组患者加服排石颗粒。两组均连续治疗4周。术后随访3个月。结果观察组总有效率为100.00%,明显高于对照组的90.00%(P<0.05)。治疗后,两组患者尿频尿急、血尿及腰痛评分均显著低于治疗前,且观察组降幅更显著(P<0.05);观察组患者残余结石排净率显著高于对照组(P<0.05),残余结石开始排出时间及排净时间均显著短于对照组(P<0.05);两组患者血清白细胞介素1(IL-1)、肿瘤坏死因子-α(TNF-α)和C反应蛋白(CRP)水平均显著下降,且观察组降幅更显著(P<0.05)。观察组不良反应发生率及术后并发症发生率均与对照组相当(6.00%比4.00%,4.00%比12.00%;P>0.05)。术后3个月内,患者均无其他严重并发症(如感染性休克、脓毒血症等)发生。结论上尿路结石患者FURSL术后联用排石颗粒与盐酸坦洛新,能加快术后残余结石排出及提高其排净率,促进临床症状缓解,减轻机体炎性反应。Objective To investigate the effect of Paishi Granules combined with tamsulosin hydrochloride on the removal of residual stones in patients with upper urinary calculi undergoing flexible ureteroscope lithotripsy(FURSL).Methods A total of 100 patients with upper urinary calculi admitted to the hospital from August 2020 to August 2021 were selected and divided into the control group and the observation group according to the random number table method,with 50 cases in each group.The patients in the two groups underwent FURSL,and they were given Tamsulosin Hydrochloride Sustained-Release Tablets after the operation.On this basis,the patients in the observation group were given Paishi Granules.Both groups were continuously treated for four weeks and followed up for three months.Results The total effective rate in the observation group was 100.00%,which was significantly higher than 90.00%in the control group(P<0.05).After treatment,the scores of frequent and urgent urination,hematuria and lumbago in the two groups were significantly lower than those before treatment,and those in the observation group were significant lower than those in the control group(P<0.05).The complete removal rate of residual stones in the observation group was significantly higher than that in the control group(P<0.05),and the duration from the end of the surgery to the beginning of residual stone removal and the duration of complete removal of residual stones in the observation group were significantly shorter than those in the control group(P<0.05).The levels of serum interleukin-1(IL-1),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the two groups were significantly lower than those before treatment,and those in the observation group were significant lower than those in the control group(P<0.05).The incidence rates of adverse drug reactions and postoperative complications in the observation group were similar to those in the control group(6.00%vs.4.00%,4.00%vs.12.00%;P>0.05).No other serious complications(such as septic shoc

关 键 词：排石颗粒 盐酸坦洛新 上尿路结石 软性输尿管镜钬激光碎石术 临床疗效 炎性反应 

分 类 号：R969.4[医药卫生—药理学]