GC-Orbitrap MS非靶向筛查进口儿童纺织品中未知化学危害物  

Non-targeted Screening of Unknown Chemical Hazards in Imported Children's Textiles by GC-Orbitrap MS

作　　者：刘雅慧 李红艳 孔祥伟 王志娟[1] 张庆[1] 马强[1] 吕庆[1] LIU Ya-hui;LI Hong-yan;KONG Xiang-wei;WANG Zhi-juan;ZHANG Qing;MA Qiang;LYU Qing(Key Laboratory of Consumer Product Quality Safety Inspection and Risk Assessment for State Market Regulation,Institute of Industrial and Consumer Product Safety,Chinese Academy of Inspection and Quarantine,Beijing 100176,China;Zhejiang Institute of Product Quality and Safety Science,Hangzhou 310018,China;Beijing Kaloon Analytical Instrument Company Limited,Beijing 101102,China)

机构地区：[1]中国检验检疫科学研究院,工业与消费品安全研究所,国家市场监管重点实验室(消费品质量安全检测与风险评估),北京100176 [2]浙江省产品质量安全科学研究院,浙江杭州310018 [3]北京凯隆分析仪器有限公司,北京101102

出　　处：《质谱学报》2023年第1期66-77,共12页Journal of Chinese Mass Spectrometry Society

基　　金：中国检科院基本科研业务费项目(2022JK13);浙江省市场监管局雏鹰计划培育项目(CY2022109)。

摘　　要：本文基于气相色谱-轨道阱高分辨质谱(GC-Orbitrap MS)建立了进口儿童纺织品中潜在化学危害物质的非靶向分析方法。通过综合评分和保留指数初步鉴定,化学电离模式确定分子式,质谱碎片离子比对区分同分异构体,化学标准品验证等4个步骤开展未知物的定性分析。在40件进口儿童纺织品中共鉴定出48种物质,包括21种酯、8种酮、6种胺、4种醚、3种醇、3种酚以及3种其他类物质;对鉴定的物质进行统计和半定量分析,其中,邻苯二甲酸二丁酯、2,4-甲苯二异氰酸酯、棕榈酸异丙酯和1,2,4-丁三醇的检出率最高。综合考虑检出率、毒性和响应强度,进一步过滤和筛选鉴定出的物质,排查儿童纺织品中具有较高风险的化学物质。该方法为筛查纺织品等产品中潜在的化学物质提供了新途径,对开展产品化学风险监测以及促进产品质量安全具有积极作用。The quality and safety of children’s textiles,especially chemical safety,is very important.The harm to children caused by using unsafe products is immeasurable.At present,the chemical safety research of textiles usually focuses on the specific target substances specified in the regulations.The detection methods are mainly to detect the content of target substances in the sample to determine whether it meets the regulatory requirements.In fact,although the known chemicals in the product meet the regulatory requirements,other unknown chemicals may exist potential hazards to children’s health.Therefore,it is necessary to screen potential chemicals in children’s textiles by non-targeted method in order to more comprehensively screen the chemical risks in product.Non-targeted analysis of potential chemical substances in imported children’s textiles using gas chromatography-Orbitrap high-resolution mass spectrometry(GC-Orbitrap MS)was established.Unknown substances were qualitatively assessed by using the comprehensive score and retention index,identifying the molecular formula by chemical ionization,comparing fragment ion data to distinguish isomers,and verifying according to chemical standards.A total of 48 substances were identified in 40 children’s textiles,including 21 esters,8 ketones,6 amines,4 ethers,3 alcohols,3 phenols and 3 other substances.The identified substances were statistically and semi-quantitatively analyzed.Dibutyl phthalate,tolylene-2,4-diisocyanate,isopropyl palmitate and 1,2,4-butanetriol were identified in the imported children’s textiles,and their detection rates were greater than or equal to 10%.The identified substances were further filtered and screened according to detection rates,toxicities and response intensities.Then the high-risk chemicals in the children’s textiles were found.This method can provide a new way for screening potential chemicals in textiles and other products,and play a positive role in carrying out product chemical risk monitoring and promoting product qu

关 键 词：儿童纺织品 非靶向筛查 气相色谱-轨道阱高分辨质谱(GC-Orbitrap MS) 

分 类 号：O657.63[理学—分析化学]