大麻素受体激活调控牙周炎症和骨改建促进牙周组织愈合  

Activation of cannabinoid receptors promotes periodontal healing by regulating periodontal inflammation and bone remodeling

作　　者：赵圆 翟浩嫣 刘春艳[1] Zhao Yuan;Zhai Haoyan;Liu Chunyan(Department of Orthodontics,School and Hospital of Stomatology,Hebei Medical University,Hebei Key Laboratory of Stomatology,Hebei Clinical Research Center for Oral Diseases,Shijiazhuang 050017,Hebei Province,China)

机构地区：[1]河北医科大学口腔医(学)院正畸科,河北省口腔医学重点实验室,河北省口腔疾病临床医学研究中心,河北省石家庄市050017

出　　处：《中国组织工程研究》2023年第26期4214-4222,共9页Chinese Journal of Tissue Engineering Research

基　　金：河北省重点研发计划(21377715D),项目参与人:刘春艳;河北省政府资助临床医学优秀人才培养项目(361029),项目负责人:刘春艳。

摘　　要：背景:大麻素受体通过与配体结合,调控牙周炎的炎症和骨量,促进牙周组织的愈合,在临床上牙周炎的预防和治疗方面具有重要意义。目的:综述大麻素受体与牙周炎的关系,主要为大麻素Ⅰ型(CB1)受体、大麻素Ⅱ型(CB2)受体与炎症和牙槽骨骨改建的关系,以及涉及的常见细胞信号传导通路,为牙周炎预防和治疗及其在临床其他领域的应用提供思路。方法:检索PubMed、万方数据库、CNKI中国期刊全文数据库1985年7月至2022年7月收录的相关文献。英文检索词为“cannabinoids receptor,CB1 receptor and periodontitis,CB2 receptor and periodontitis,CB1 receptors and bone remodeling,CB2 receptors and bone remodeling,CB1 receptors and signaling pathways,CB2 receptors and signaling pathways”,中文检索词为“大麻素受体,CB1受体和牙周炎,CB2受体和牙周炎,CB1受体和骨改建,CB2受体和骨改建,CB1受体和信号通路、CB2受体和信号通路”,最终纳入107篇文献进行归纳总结。结果与结论:①内源性大麻素系统包含多种受体,其中最具有代表性的为CB1和CB2受体,均属于G蛋白偶联超家族成员;二者在牙周组织中均存在表达;②在天然配体或人工合成激动剂的作用下,大麻素受体可通过不同的代谢通路在体内外产生特定的生理效应,从而调控牙周炎局部的炎症和骨细胞的生成和分化,最终影响炎症和骨量;③进一步研究大麻素受体与牙周炎炎症和牙槽骨骨形成、骨吸收的关系,以及涉及到的常见信号通路——丝裂原活化蛋白激酶(MAPK)信号通路、NF-κB信号通路,为临床上牙周炎的预防和治疗提供新的思路成为目前研究的重点。BACKGROUND:Cannabinoid receptors,by binding to ligands,modulate inflammation and bone volume in periodontitis and promote healing of periodontal tissue,which is of great significance in the clinical prevention and treatment of periodontitis.OBJECTIVE:To review the relation between cannabinoid receptors and periodontitis,mainly cannabinoid type I(CB1)receptor and cannabinoid type II(CB2)receptor in relation to inflammation and remodeling of the alveolar bone,and the common cellular signaling pathways involved,thereby providing ideas for the prevention and treatment of periodontitis and its application in other clinical areas.METHODS:Relevant literature included in PubMed,WanFang database,and CNKI Database from July 1985 to July 2022 was searched.Search terms were“cannabinoids receptor,CB1 receptor and periodontitis,CB2 receptor and periodontitis,CB1 receptors and bone remodeling,CB2 receptors and bone remodeling,CB1 receptors and signaling pathways,CB2 receptors and signaling pathways”in English and Chinese.Totally 107 papers were finally included for review.RESULTS AND CONCLUSION:The endogenous cannabinoid system contains multiple receptors,the most representatives of which are CB1 and CB2 receptors,two members of the G protein-coupled superfamily.Both CB1 and CB2 receptors are expressed in periodontal tissue.In the presence of natural ligands or synthetic agonists,cannabinoid receptors can produce specific physiological effects in vitro and in vivo through different metabolic pathways.Then they can regulate the local inflammation and osteocyte generation and differentiation in periodontitis,ultimately influencing inflammation and bone mass.Further studies are needed on the relation between cannabinoid receptors and periodontitis inflammation and alveolar bone formation and resorption,as well as the common signaling pathways involved,such as mitogen-activated protein kinase signaling pathway and nuclear factor-κB signaling pathway.It has become the focus of current research to provide new ideas for the preve

关 键 词：大麻素 CB1受体 CB2受体 牙周炎 炎症 骨改建 MAPK信号通路 NF-κB信号通路 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R781.4