绍沙-7味丸对PCI围手术期患者血管内皮功能及炎症因子的影响  

Effect of Mongolian Medicine Shaosha-7 Pills on Vascular Endothelial Function and Inflammatory Factor in Perioperative Period Patients Treated by PCI

作　　者：梁车格乐 圆圆 包布仁白乙拉[1] LIANG Chegele;Yuanyuan;BAO Burenbaiyila(Affiliated Hospital,Inner Mongolia Minzu University,Tongliao 028000,China)

机构地区：[1]内蒙古民族大学附属医院,内蒙古通辽028000

出　　处：《内蒙古民族大学学报（自然科学版）》2022年第6期513-517,共5页Journal of Inner Mongolia Minzu University：Natural Sciences

基　　金：内蒙古自治区自然科学基金项目(2017MS-LH0818)。

摘　　要：目的:探讨蒙药绍沙-7味丸对经皮冠状动脉介入术(PCI)围手术期患者炎症因子及血管内皮功能治疗的影响。方法:选取2021年3月至10月在内蒙古民族大学附属医院诊断为冠心病拟择期行PCI治疗的患者60例,随机分为对照组和观察组各30例,入院后均给予冠心病标准化治疗,对照组在PCI术前1 d给予阿司匹林肠溶片、硫酸氢氯吡格雷和瑞舒伐他汀钙片进行治疗;观察组在对照组治疗基础上给予绍沙-7味丸治疗。检测两组PCI术前1 d、术后1 d、术后3 d、术后7 d的一氧化氮(NO)、血浆内皮素-1(ET-1)、细胞间黏附因子-1(ICAM-1)、血管性假血友病因子(v WF)和血流依赖性舒张功能(FMD)等影响血管内皮功能的指标以及炎症因子-α(TNF-α)、白细胞介素-6(IL-6)和C反应蛋白(CRP)水平变化情况。结果:与PCI术前相比,两组NO和FMD水平逐渐减少,ET-1、ICAM-1和vWF的含量逐渐升高,炎症因子TNF-α、IL-6和CRP减少,并且观察组的上述对应指标优于对照组。结论:蒙药绍沙-7味丸显著改善PCI围手术期患者的血管内皮功能及炎症因子水平,在临床上值得推广应用。Objective:To investigate the effect of Mongolian medicine Shaosha-7 pills on the treatment of inflammatory factors and vascular endothelial function in perioperative period patients undergoing percutaneous coronary intervention(PCI).Methods:60 patients who scheduled for the PCI treatment were randomly divided into a control group(n=30)and an observation group(n=30).Both groups were given standardized treatment for coronary heart disease after admission,the control group was given Aspirin Enteric-coated Tablets,Clopidogrel bisulfate and Rosuvastatin Calcium Tablets 1 day before PCI,and the observation group was treated with Shaosha-7pills on the basis of control group.The levels of vascular endothelial function affecting indicators such as nitric oxide(NO),plasma endothelin-1(ET-1),intercellular adhesion factor-1(ICAM-1),von Willebrand factor(vWf),flow-mediated dilation(FMD)and so on,and the changes of inflammatory factor-α(TNF-α)level,interleukin-6(IL-6)level and C-reactive protein(CRP)level in the two groups were detected 1 d before PCI and 1,3 and 7 d after PCI.Results:Compared with before PCI,the levels of NO and FMD in the two groups gradually decreased,the contents of ET,ICAM-1 and v WF gradually increased,the inflammatory factors TNF-α,IL-6 and CRP decreased,and the above corresponding indexes in the observation group were better than those in the control group.Conclusion:Mongolian medicine Shaosha-7 pills can significantly improve the vascular endothelial function and the level of inflammatory factors in perioperative PCI patients,which is worth promoting and applying in clinical practice.

关 键 词：绍沙-7味丸 冠状动脉介入 围手术期 炎症因子 内皮细胞功能 

分 类 号：R541.4[医药卫生—心血管疾病]