益生菌辅助治疗老年腹部外伤合并肝损伤患者的临床疗效及其对患者肠道菌群的影响  

Effect of Probiotics on Intestinal Flora in Elderly Patients with Abdominal Trauma and Liver Injury

作　　者：王铭 黎冬梅[2] 王宁宁 高庆剑 WANG Ming;LI Dong-mei;WANG Ning-ning(General Surgery,the Affiliated Hospital of Xi'an Medical College,Xi'an Shaanxi 710309)

机构地区：[1]西安医学高等专科学校附属医院普外科,陕西西安710309 [2]宝鸡市中医医院药剂科,陕西宝鸡721000

出　　处：《医学临床研究》2022年第12期1862-1865,共4页Journal of Clinical Research

摘　　要：【目的】益生菌辅助治疗老年腹部外伤合并肝损伤患者的临床疗效及其对患者肠道菌群的影响。【方法】选取西安医学高等专科学校附属医院收治的116例腹部外伤合并肝损伤的老年患者,采用随机数字表法将其分为观察组与对照组,每组58例。对照组患者在常规治疗的基础上给予人工肝支持系统治疗,观察组在对照组的基础上加用益生菌辅助治疗。比较两组患者临床疗效,比较两组患者治疗前后肝功能指标[丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBIL)、白蛋白(ALB)]、肠道菌群数(大肠杆菌、双歧杆菌、乳酸杆菌、葡萄球菌),并记录两组患者并发症发生情况。【结果】观察组总有效率为84.48%(49/58),高于对照组的65.52%(38/58),差异有统计学意义(χ^(2)=5.56,P=0.018)。治疗后,两组患者血清ALT、AST、TBIL均低于本组治疗前,ALB高于本组治疗前,且观察组与对照组比较,差异均有统计学意义(均P<0.05);两组患者大肠杆菌、葡萄球菌数量均低于本组治疗前,双歧杆菌、乳酸杆菌数量均显著高于本组治疗前,且观察组与对照组比较,差异有统计学意义(P<0.05)。两组患者治疗期间并发症发生率比较,差异无统计学意义(χ^(2)=0.33,P=0.56)。【结论】益生菌辅助治疗老年腹部外伤合并肝损伤患者的临床疗效较好,可明显改善患者的肝功能,调节肠道菌群,且安全性较高,值得临床推广。【Objective】To observe the effect of probiotics on intestinal flora in elderly patients with abdominal trauma combined with liver injury.【Methods】A total of 116 elderly patients with abdominal trauma combined with liver injury were randomly divided into the observation group and the control group,with 58 patients in each group.The patients in both groups received surgical treatment such as drainage,ligation or partial resection according to the situation of abdominal trauma and routine perioperative therapy.The patients in the control group were treated with artificial liver support system on this basis,while the patients in the observation group were treated with probiotics on this basis,To compare the clinical efficacy of the two groups of patients after treatment,to compare the levels of various indicators of liver function[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),albumin(ALB)],and the number of intestinal flora(Escherichia coli,bifidobacteria,lactobacillus,staphylococcus)of the two groups of patients before and after treatment,and to count and record the occurrence of postoperative complications of the two groups of patients during treatment.【Results】The total effective rate of the observation group after treatment was 84.48%,which was significantly higher than that of the control group(65.52%),with a statistically significant difference(P<0.05).After treatment,ALT,AST and TBIL of the two groups were significantly lower than that before treatment,and ALB was significantly higher than that before treatment,with a statistically significant difference(P<0.05);After treatment,ALT,AST and TBIL in the observation group were significantly lower than those in the control group,and ALB was significantly higher than those in the control group,with a statistically significant difference(P<0.05).After treatment,the number of Escherichia coli and Staphylococcus in the two groups was significantly lower than that before treatment,and the number of Bifidobacterium and La

关 键 词：腹部损伤/并发症 肝/损伤 鼠李糖乳杆菌 胃肠道微生物组 老年人 

分 类 号：R826.65[医药卫生—临床医学]