床旁血滤联合无创通气治疗难治性心衰的研究  

Study on bedside hemofiltration combined with non-invasive ventilation in the treatment of refractory heart failure

作　　者：郭文晏 GUO Wen-yan(Zhongshan Hospital Affiliated to Dalian University,Dalian 116001,China)

机构地区：[1]大连大学附属中山医院,116001

出　　处：《中国实用医药》2023年第1期56-58,共3页China Practical Medicine

摘　　要：目的 分析床旁血液滤过(血滤)联合无创通气治疗难治性心力衰竭(心衰)的效果。方法 80例难治性心衰患者,按照随机数字表法分为对照组和观察组,每组40例。对照组患者接受无创通气治疗,观察组患者接受床旁血滤联合无创通气治疗。比较两组患者治疗前后N末端B型利钠肽前体(NT-proBNP)、氧分压、肌酐水平及治疗效果。结果 治疗后,观察组患者NT-proBNP、肌酐水平分别为(565.0±30.1)pg/ml、(76.4±3.0)μmol/L,低于对照组的(876.0±29.3)pg/ml、(87.4±2.9)μmol/L,氧分压(92.40±3.02)mm Hg(1 mm Hg=0.133 kPa)高于对照组的(87.40±2.95)mm Hg,差异均有统计学意义(P<0.05)。观察组患者显效16例,有效22例,无效2例,总有效率为95.00%;对照组患者显效13例,有效18例,无效9例,总有效率为77.50%。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论 床旁血滤联合无创通气治疗难治性心衰能够改善患者NT-proBNP、氧分压、肌酐水平,提升治疗效果,值得临床中推广使用。Objective To analyze the effect of bedside hemofiltration combined with non-invasive ventilation in the treatment of refractory heart failure. Methods A total of 80 patients with refractory heart failure were divided into control group and observation group according to random numerical table, with 40 patients in each group. Patients in the control group received non-invasive ventilation, while patients in the observation group received bedside hemofiltration combined with non-invasive ventilation. The N-terminal pro-B type natriuretic peptide(NT-proBNP), partial pressure of oxygen, creatinine level before and after treatment, and therapeutic effect were compared between the two groups. Results After treatment, the levels of NT-proBNP and creatinine in the observation group were(565.0±30.1) pg/ml and(76.4±3.0) μmol/L, which lower than(876.0±29.3) pg/ml and(87.4±2.9) μmol/L in the control group;the partial pressure of oxygen(92.40±3.02) mm Hg(1 mm Hg=0.133 kPa) in the observation group was higher than(87.40±2.95) mm Hg in the control group;the differences were statistically significant(P<0.05). In the observation group, 16 cases were markedly effective, 22 cases were effective, 2 cases were ineffective, and the total effective rate was 95.00%;in the control group, 13 cases were markedly effective, 18 cases were effective, 9 cases were ineffective, and the total effective rate was 77.50%.The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). Conclusion Bedside hemofiltration combined with non-invasive ventilation can improve NT-proBNP, partial pressure of oxygen and creatinine levels in patients with refractory heart failure, and enhance the therapeutic effect, which is worthy of clinical promotion and application.

关 键 词：床旁血液滤过 无创通气治疗 难治性心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]