TGFBR基因多态性与主动脉夹层的相关性研究  

Association Between Gene Polymorphism of Transforming Growth Factor-βReceptor and Aortic Dissection

作　　者：陶黎阳 解晓东 胡丙杰 Tao Liyang;Xie Xiaodong;Hu Bingjie(Department of Pathology,School of Basic Medical Sciences,Guangzhou Medical University,Guangzhou 5114361)

机构地区：[1]广州医科大学基础医学院病理学教研室,广州511436

出　　处：《国际老年医学杂志》2023年第1期14-18,共5页International Journal of Geriatrics

基　　金：2021年广州市科技局基础研究计划基础与应用基础研究项目(202102080092)。

摘　　要：目的评价转化生长因子-β受体(TGFBR)基因多态性与主动脉夹层发病风险的关联。方法检索中国知网中国期刊全文数据库、万方数据库、维普数据库、美国国立医学图书馆(PubMed)、荷兰医学文摘(EMBASE)、Cochrane Library数据库,获取与TGFBR与主动脉夹层易感性的文献,检索时间截止2022年3月1日。采用RavMan5.3软件进行meta分析。结果纳入5篇文献,包括1277例病例和2019例对照。TGFBR1(rs1626340)位点等位基因模型(A/G)meta分析结果显示A等位基因更容易导致主动脉夹层疾病的发生(OR=1.25,95%CI:1.11~1.42,P=0.0004);显性基因模型(AG+AA/GG)meta分析结果显示,具有AG+AA基因的人群可能更易发生主动脉夹层(OR=1.45,95%CI:1.09~1.93,P=0.01);隐性基因模型(AA/AG+GG)的meta分析结果显示,AG+GG基因与主动脉夹层患病风险无相关性(OR=0.93,95%CI:0.66~1.32,P=0.70)。TGFBR2(rs4522809)位点等位基因模型(OR=1.01,95%CI:0.75~1.36,P=0.95)、显性基因模型(OR=1.11,95%CI:0.84~1.46,P=0.46)、隐性基因模型(OR=1.15,95%CI:0.81~1.64,P=0.44)的meta分析结果显示,TGFBR2(rs4522809)位点多态性与主动脉夹层发病风险无显著相关性(P>0.05)。结论TGFBR1基因rs1626340位点多态性与主动脉夹层疾病显著相关。Objective To evaluate the association between gene polymorphism of transforming growth factor-βreceptor(TGFBR)and the risk of aortic dissection.Methods Literature search was conducted in CNKI,Wanfang,VIP,PubMed,EMBASE,and Cochrane Library databases up to March 1,2022,and studies related to TGFBR and susceptibility to aortic dissection were identified.Ravman 5.3 software was used for meta-analysis.Results Five studies were selected in this study,including 1277 patients and 2019 controls.The meta-analysis of TGFBR1(rs1626340)allele model(A/G)showed that allele A was more likely to lead to aortic dissection(OR=1.25,95%CI:1.11-1.42,P=0.0004).The meta-analysis of TGFBR1(rs1626340)dominant gene model(AG+AA/GG)showed that the people with gene(AG+AA)was more susceptible to aortic dissection(OR=1.45,95%CI:1.09-1.93,P=0.01).The meta-analysis of TGFBR1(rs1626340)recessive gene model(AA/AG+GG)showed that gene(AG+GG)was not associated with aortic dissection(OR=0.93,95%CI:0.66-1.32,P=0.70).The meta-analysis of allele model(OR=1.01,95%CI:0.75-1.36,P=0.95),dominant gene model(OR=1.11,95%CI:0.84-1.46,P=0.46),and recessive gene model(OR=1.15,95%CI:0.81-1.64,P=0.44)of TGFBR2(rs4522809)showed that there was no significant association between TGFBR2(rs4522809)polymorphism and risk of aortic dissection(P>0.05).Conclusion The gene polymorphism of TGFBR1(rs1626340)is significantly associated with the risk of aortic dissection.

关 键 词：主动脉夹层 转化生长因子-Β受体 单核苷酸多态性 

分 类 号：R543.1[医药卫生—心血管疾病]