原发性肾病综合征患儿T淋巴细胞亚群、NEFA、ALB水平及临床意义  

T LYMPHOCYTE SUBSETS,NEFA,ALB LEVELS AND THEIR CLINICAL SIGNIFICANCE IN CHILDREN WITH PRIMARY NEPHROTIC SYNDROME

作　　者：张艳萍 曹卫红[1] 何玲[1] 张召艳 彭经纬[1] ZHANG Yanping;CAO Weihong;HE Ling;ZHANG Zhaoyan;PENG Jingwei(Renhe Hospital Affiliated to Three Gorges University,Yichang 443000,China)

机构地区：[1]三峡大学附属仁和医院,湖北省宜昌市443000

出　　处：《中国煤炭工业医学杂志》2022年第5期481-485,共5页Chinese Journal of Coal Industry Medicine

基　　金：湖北省自然科学基金项目(编号:2021CFB414)。

摘　　要：目的 探讨原发性肾病综合征患儿T淋巴细胞亚群、游离脂肪酸(NEFA)、白蛋白(ALB)水平及与病情的关系。方法 选取原发性肾病综合征患儿102例(观察组),同时选取健康儿童60例作为对照组,检测T淋巴细胞亚群、NEFA、ALB水平,同时分析观察组激素耐药型(n=77)和敏感型患儿(n=25)指标差异。结果 观察组CD3+、CD8+、调节性T细胞(Treg)和NEFA/ALB分别为(74.40±4.22)%、(29.01±4.82)%、(7.01±1.82)%和(25.81±9.21)μmol/g,明显高于对照组(P<0.05),而ALB为(22.81±3.39)g/L,明显低于对照组(P<0.05);观察组激素耐药型患儿CD3+、CD8+、Treg和NEFA/ALB分别为(84.23±9.33)%、(31.81±5.02)%、(7.60±1.19)%和(29.40±4.3)μmol/g,明显高于激素敏感型患儿(P<0.05),而ALB为(19.05±3.60)g/L,明显低于激素敏感型患儿(P<0.05);观察组治疗后CD3+、CD8+、Treg和NEFA/ALB较治疗前降低(P<0.05),而ALB较治疗前升高(P<0.05);NEFA/ALB与BUN呈正相关(r=0.300,P<0.05)。结论 原发性肾病综合征患儿CD3+、CD8+、Treg、ALB及NEFA/ALB水平异常,在疾病的发生发展过程中有重要作用。Objective To investigate the relationship between T lymphocyte subsets, free fatty acid(NEFA) and albumin(ALB) levels in children with primary nephrotic syndrome.Methods one hundred and two cases(observation group) of children with primary nephrotic syndrome were selected, and sixty cases of healthy children were selected as the control group, T lymphocyte subsets, NEFA and ALB levels were detected, and the differences of indicators between hormone resistant children(n=77) and sensitive children(n=25) in the observation group were analyzed.Results In the observation group, CD3+,CD8+,regulatory T cells(Treg) and NEFA/ALB were(74.40±4.22) %,(29.01±4.82) %,(7.01±1.82) % and(25.81±9.21) μmol/g, which were significantly higher than the control group(P<0.05),while ALB was(22.81±3.39) g/L,which was significantly lower than the control group(P<0.05);CD3+,CD8+,Treg and NEFA/ALB in the observation group were(84.23±9.33) %,(31.81±5.02) %,(7.60±1.19) % and(29.40±4.3) μmol/g, which were significantly higher than those in the hormone sensitive group(P<0.05),while the ALB was(19.05±3.60) g/L,which was significantly lower than those in the hormone sensitive group(P<0.05);In the observation group, CD3+,CD8+,Treg and NEFA/ALB decreased after treatment(P<0.05),while ALB increased after treatment(P<0.05);NEFA/ALB was positively correlated with BUN(r=0.300,P<0.05).Conclusion There are abnormal levels of CD3+,CD8+,Treg, ALB and NEFA/ALB in children with primary nephrotic syndrome, plays an important role in the occurrence and development of diseases.

关 键 词：原发性肾病综合征 T淋巴细胞亚群 游离脂肪酸 白蛋白 

分 类 号：R726.9[医药卫生—儿科]